REVIEW

Cell Research (1997)7:127-142
© 1997 SIBS, CAS All rights reserved 1001-0602/97

Chromatin remodeling regulated by steroid and nuclear receptors.

Laboratory of Molecular Embryology, Nat'l Institute of Child Health and Human Development, Bethesda, MD 20892-5431, USA.

Correspondence: Wolffe AP. E-mail: awlme@helix.nih.gov

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Abstract

Coactivators and corepressors regulate transcription by controlling interactions between sequence-specific transcription factors, the basal transcriptional machinery and the chromatin environment. This review consider the access of nuclear and steroid receptors to chromatin, their use of corepressors and coactivators to modify chromatin structure and the implications for transcriptional control. The assembly of specific nucleoprotein architectures and targeted histone modification emerge as central controlling elements for gene expression.

Keywords : Steroid receptor, nuclear receptor, coactivator, corepressor, transcriptional activation, nucleosome positioning, histone modification, transcriptional repression.