REGULAR ARTICLES
Cell Research (1998)8:241-247
© 1998 SIBS, CAS All rights reserved 1001-0602/98
Enhanced radioimmunotherapeutic efficacy of a monoclonal antibody
cocktail against SMMC-7721 human hepatocellular carcinoma.
Song YQ, Wang GF, Dai XL, Xie H.
Shanghai Institute of Cell Biology, Chinese Academy of Sciences,
China.
Correspondence:
Xie H |
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Xie H
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The improved tumoricidal effect of the radioantibody mixture ("cocktail")
has been reported recently for the treatment of colon tumor. In the present
study, we demonstrated the enhanced radioimmunotherapeutic efficacy of a
monoclonal antibody (MAb) cocktail against human hepatocellular carcinoma.
Therapeutic efficacy was determined by measuring the change in tumor size
over a period, determining the percentage of growth inhibition of each treatment
at various times after radioantibody therapy. Radioimmunotherapy of SMMC-7721
human hepatoma xenografts in athymic nude mice with combination of 131I-labeled
Hepama-1 and 131I-labeled 9403 mouse MAbs was more effective than using
either Hepeam-1 or 9403 MAb alone The MAb cocktail could target a greater
number of hepatoma cells and increase the magnitude of hepatoma cell uptake
of radioantibodies. The in vitro results explain the enhanced effect of
the MAb cocktail in in vivo model system.
Keywords : Mouse
monoclonal antibody, human hepatocellular carcinoma, radioimmunotherapy,
antibody cocktail. |
