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Cell Research (1999), 9, 243-253
Department of Biophysics and Cell Biology, Shanghai Se- ABSTRACT
Endocytic tracers and marker enzyme of lysosomes
were used in the present study to analyze the processes of autophagocytosis and
endocytosis, and the convergent point of these two pathways in Leydig cells. The
endocytic and autophagic compartments can be easily identified in Leydig cells,
which makes easier to define the stages of two pathways than was possible
before. The evidences indicated that the late endosomes (dense MVBs) deliver
their endocytosed gold tracers together with lysosomal enzymes to the early
autophagosomes and they are the convergent point of the two pathways. During
this convergent process, the early autophagosomes transform into late
autophagosomes and the late endosomes transform into mature lysosomes. Key words: Autophagocytosis, endocytosis, endosomes, lysosomes.
The convergent point of the endocytic and autophagic pathways
in leydig cells
YI Jing, Xue Ming TANG*
cond Medical University, Shanghai 200025, China
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copyright©2006 2006 Institute of Biochemistry and Cell Biology,SIBS,CAS
ISSN:1001-0602(Print),1748-7838(Online);CN:31-1568
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