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REGULAR ARTICLESS
Cell Research (1999), 9, 315-325
Evidence for a mouse brain-specific variant of a-tubulin
KONG Ling Wei1, Xiao Yan DING2,
Hiroshi KITANI3, Robert SHIURBA4, Nai He JING1,*
1. Shanghai Institute of Biochemistry, Chinese Academy of
Sciences, 320 Yue Yang Road, Shanghai 200031, China
2. Shanghai Institute of Cell Biology, Chinese Academy of Sciences, 320 Yue Yang
Road, Shanghai 200031, China
3. National Institute of Animal Health, 3-1-1 Kannondai, Tsukuba 305, Japan
4. Misato Plaheat Mfg., Ltd., 521-18 Kamiuwada, Satte-shi, Saitama 340-0124,
Japan
ABSTRACT
While studying the neural precursor cell
intermediate filament protein known as nestin in the developing mouse brain, we
observed a strong cross-reaction of our nestin antibody with a 50 kDa protein
that appeared on embryonic day 10 and continued to accumulate until postnatal
day 1. Here we report evidence that this protein is a brain-specific variant
form of a-tubulin and discuss its implications.
Key words: Brain-specific a-tubulin,
Post-translational modification, Nestin.
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