REGULAR ARTICLES Cell Research (2001); 11(2):89-94

The involvement of p38 MAPK in transforming growth factor b1-induced apoptosis in murine hepatocytes

LIAO Jin Hui, Jun Song CHEN, Min Qiang CHAI, Sheng ZHAO, Jian Guo SONG^*

State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China

ABSTRACT

    We reported in this manuscript that TGF-b 1 induces apoptosis in AML12 murine hepatocytes, which is associated with the activation of p38 MAPK signaling pathway. SB202190, a specific inhibitor of p38 MAPK, strongly inhibited the TGF-b1-induced apoptosis and PAI-1 promoter activity. Treatment of cells with TGF-b1 activates p38. Furthermore, over-expression of dominant negative mutant p38 also reduced the TGF-b1-induced apoptosis. The data indicate that the activation of p38 is involved in TGF-b1-mediated gene expression and apoptosis.

Key words: Transforming growth factor b, apoptosis, p38, hepatocyte, signal transduction.

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