REVIEW Cell Research (2002); 12(1):9-18

MAPK signal pathways in the regulation of cell proliferation in mammalian cells

Wei ZHANG, Hui Tu LIU^*

The Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China

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ABSTRACT

MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. At least three MAPK families have been characterized: extracellular signal-regulated kinase (ERK), Jun kinase (JNK/SAPK) and p38 MAPK. The above effects are fulfilled by regulation of cell cycle engine and other cell proliferation related proteins. In this paper we discussed their functions and cooperation with other signal pathways in regulation of cell proliferation.

Key words: MAPK, ERK, JNK/SPAK, p38, cell proliferation, cross-talk.

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