Table of contents

Browse Archive:

Vol.13 No.1 2003
The mode of action of nucleotide reverse transcriptase inhibitors is shown.
[Cover Caption]

	MINIREVIEW		Pages
	New insights into the immunology and evolution of HIV Justin STEBING, Steve PATTERSON, Frances GOTCH [Abstract]		1-8

	REVIEW		Pages
	Hypertrophic cardiomyopathy: from gene defect to clinical disease Man Wei CHUNG, Tatiana TSOUTSMAN, Christopher SEMSARIAN [Abstract]		9-20

	REGULAR ARTICLES		Pages
	Regulation of swelling-activated chloride channels in embryonic chick heart cells Hua WEI, Yan Ai MEI, Jia Ting SUN, Han Qing ZHOU, Zhi Hong ZHANG [Abstract]		21-28

	Ohmefentanyl stereoisomers induce changes of CREB phosphorylation in hippocampus of mice in conditioned place preference paradigm Can GAO, Li Wei CHEN, Jie CHEN, Xue Jun XU, Zhi Qiang CHI [Abstract]		29-34

	Construction, expression and characterization of the engineered antibody against tumor surface antigen, p185c-erbB-2 Lian Sheng CHENG, Ai Ping LIU, Jia Hong YANG, Yan Qiu DONG, Liang Wei LI, Jing WANG, Chao Chen WANG, Jing LIU [Abstract]		35-48

	Clusterin mRNA expression in apoptotic and activated rat thymocytes Jung Hyun PARK, Jee Sun PARK, Sung Kyu JU, Kwan Bok LEE, Yoo Kyoung PARK, Myung Hee KANG, Shin Young NA, Kwan Hee YOU [Abstract]		49-58

	Identification of ABA-responsive genes in rice shoots via cDNA macroarray Fang LIN, Shou Ling XU, Wei Min NI, Zhao Qing CHU, Zhi Hong XU, Hong Wei XUE [Abstract]		59-68

	Cover The mode of action of nucleotide reverse transcriptase inhibitors is shown. Unlike the nucleoside reverse transcriptase inhibitors, which must undergo 3 intracellular phosphorylation steps for activation, nucleotide analogues such as tenofovir require only 2 such steps. This reduction in the phosphorylation requirement has the potential to produce more rapid and complete conversion of the drug to its pharmacologically active metabolite. See Mini-review by Justin Stebbing et al in Page 1 this issue.

	Indexed / Abstracted in Index Medicus; MEDLINE on MEDLARS system; Science Citation Index-Expanded as SciSearch and ISI Web of Science on the Internet-research Alert, BIOSIS database, ChinaInfo (CD & Web) and Chinese Academic Journal (CD & Web) et al. Full text of the journal from with Vol 9(1) 1999 is online at http://www.cell-research.com, which has been linked to PubMed and AmedeoGroup as http://www.freemedicaljournals.com

	Acknowledgments This journal is supported by Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, granted by the Publishing Foundation of Chinese Academy of Sciences and National Natural Science Foundation of China (No. 30224811).

ISSN:1001-0602(Print),1748-7838(Online);CN:31-1568

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