REVIEW

Cell Research (2003); 13(2):69-81

Function and regulation of Aurora/Ipl1p kinase family in cell division

Yu Wen KE¹, Zhen DOU¹, Jie ZHANG¹, Xue Biao YAO^1,2,*

¹Laboratory for Cell Dynamics, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China
²Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA

Received Oct-13-2002 Revised Dec-9-2002 Accepted Dec-13-2002

Correspondence: Xue Biao YAO 0086-551-3607141 (phone) 0086-551-3607141 (fax) yaoxb@ustc.edu.cn

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During mitosis, the parent cell distributes its genetic materials equally into two daughter cells through chromosome segregation, a complex movements orchestrated by mitotic kinases and its effector proteins. Faithful chromosome segregation and cytokinesis ensure that each daughter cell receives a full copy of genetic materials of parent cell. Defects in these processes can lead to aneuploidy or polyploidy. Aurora/Ipl1p family, a class of conserved serine/threonine kinases, plays key roles in chromosome segregation and cytokinesis. This article highlights the function and regulation of Aurora/Ipl1p family in mitosis and provides potential links between aberrant regulation of Aurora/Ipl1p kinases and pathogenesis of human cancer.

Key words: Aurora (Ipl1p), mitosis, and cancer.