REVIEWS

Cell Research (2004); 14(6):441-449

Negative regulation of TGF-¦Â signaling in development

Ye Guang Chen*, An ming Meng*

The State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China

Correspondence: Ye Guang CHEN ygchen@mail.tsinghua.edu.cn and An Ming MENG mengam@mail.tsinghua.edu.cn

Table of Contents Download as printable (PDF) file -317K Full Text (html)file Search Medline for articles by: Ye Guang CHEN | An Ming MENG

Abstract

The TGF-¦Â superfamily members have important roles in controlling patterning and tissue formation in both invertebrates and vertebrates. Two types of signal transducers, receptors and Smads, mediate the signaling to regulate expression of their target genes. Despite of the relatively simple signal transduction pathway, many modulators have been found to contribute to a tight regulation of this pathway in a variety of mechanisms. This article reviews the negative regulation of TGF-¦Â signaling with focus on its roles in vertebrate development.

Keywords: TGF-¦Â, BMP, Nodal, Activin, antagonist, development, negative regulation.