MINIREVIEWS Cell Research, 15(1):49-51, Jan 2005 HGF/SF-Met signaling in tumor progression Chong Feng GAO, George F. VANDE WOUDE* Laboratory of Molecular Oncology, Van Andel Research Institute,#333 Bostwick Ave., N.E, Grand Rapids, MI 49503, USA
Tumor progression is a multi-step process that requires a sequential selection of specific malignant phenotypes. Met activation may induce different phenotypes depending on tumor stage: inducing proliferation and angiogenesis in primary tumors, stimulating motility to form micrometastases, and regaining the proliferation phenotype to form overt metastases. To study how HGF/SF-induced proliferative phenotypes switch to the invasive phenotype is important for understanding the mechanism of tumor progression and will provide an attractive target for cancer intervention and therapy. Keywords: HGF/SF-Met, signaling, tumor progression. |
copyright©2006 Institute of Biochemistry and Cell Biology,SIBS,CAS
ISSN:1001-0602(Print),1748-7838(Online);CN:31-1568
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