EPIDEMIOLOGY AND SOCIAL STUDIES

Cell Research, 15(11-12):833-842, Nov-Dec 2005

Global human genetics of HIV-1 infection and China

Tuo Fu ZHU ^1-3,*, Tie Jian FENG ⁴, Xin XIAO⁵, Hui WANG⁶, Bo Ping ZHOU⁶

¹Departments of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195-8070, USA
²Departments of Microbiology, University of Washington School of Medicine, Seattle, WA 98195-8070, USA
³Programs in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98195-8070, USA
⁴Shenzhen Center for Disease Control and Prevention, Shenzhen, China,
⁵Department of Neonatology, Perinatal Medicine Center, Medical College of Jinan University, Guangzhou, China
⁶Shenzhen Municipal Hospital of Infectious Diseases, Shenzhen, China.

Correspondence: Tuo Fu ZHU 206-732-6079 (phone) 206-732-6109 (fax) E-mail:tzhu@u.washington.edu

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Abstract

Genetic polymorphisms in human genes can influence the risk for HIV-1 infection and disease progression, although the reported effects of these alleles have been inconsistent. This review highlights the recent discoveries on global and Chinese genetic polymorphisms and their association with HIV-1 transmission and disease progression.

Keywords: HIV, genetic polymorphisms, China.