Briefings

Cell Research, 15(2):97-98, Feb 2005

SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci

Yong Yong Shi^1,2, Lin He^2,3,*

¹Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China;
²Institute for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, China;
³NHGG, Bio-X Center, Shanghai Jiao Tong University, Shanghai, China

Received, Jan 3, 2005 Revised, Feb 5, 2005 Accepted, Feb 6, 2005

Correspondence: Lin He 86-21-62822491 (phone) 86-21-62822491 (fax) helin@nhgg.org Shanghai Jiao Tong University, Bio-X Center, Hao Ran Building, 1954 Hua Shan Road, Shanghai 200030, China; or Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China.

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Abstract

In multiloci-based genetic association studies of complex diseases, a powerful and high efficient tool for analyses of linkage disequilibrium (LD) between markers, haplotype distributions and many chi-square/p values with a large number of samples has been sought for long. In order to achieve the goal of obtaining meaningful results directly from raw data, we developed a robust and user-friendly software platform with a series of tools for analysis in association study with high efficiency. The platform has been well evaluated by several sets of real data.

Keywords: software, linkage disequilibrium, haplotype analysis, genetic association study.