REVIEW Cell Research, 15(4):228-236, Apr 2005 14-3-3 proteins—an update Paulette Mhawech* Department of Pathology and Laboratory Medicine at Roswell Park Cancer Institute,Elm and Carlton Streets . Buffalo, New York14263, USA
14-3-3 is a highly conserved acidic protein family, composed of seven isoforms in mammals. 14-3-3 protein can interact with over 200 target proteins by phosphoserine-dependent and phosphoserine-independent manners. Little is known about the consequences of these interactions, and thus are the subjects of ongoing studies. 14-3-3 controls cell cycle, cell growth, differentiation, survival, apoptosis, migration and spreading. Recent studies have revealed new mechanisms and new functions of 14-3-3, giving us more insights on this fascinating and complex family of proteins. Of all the seven isoforms, 14-3-3¦Ä seems to be directly involved in human cancer. 14-3-3¦Ä itself is subject to regulation by p53 upon DNA damage and by epigenetic deregulation. Gene silencing of 14-3-3¦Ä by CpG methylation has been found in many human cancer types. This suggests that therapy-targeting 14-3-3¦Ä may be beneficial for future cancer treatment. Keywords: 14-3-3 function, 14-3-3¦Ä, CpG methylation, target therapy. |
copyright©2006 Institute of Biochemistry and Cell Biology,SIBS,CAS
ISSN:1001-0602(Print),1748-7838(Online);CN:31-1568
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