REVIEW

Cell Research (2006)16: 799-808
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High-density lipoproteins: an emerging target in the prevention of cardiovascular disease

Belinda A Cutri, Neil J Hime, Stephen J Nicholls

¹The Heart Research Institute, Camperdown, Sydney, NSW 2050, Australia; ²Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA; ³Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Mail Code JJ65, 9500 Euclid Avenue, Cleveland, OH 44195, USA

Correspondence: Stephen J Nicholls Tel: +1-216-445-4062; Fax: +1-216-445-5497; E-mail: nichols1@ccf.org

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High-density lipoproteins (HDLs) have been well established to protect against the development of atherosclerotic cardiovascular disease. It has become apparent that in addition to the promotion of reverse cholesterol transport, HDLs possess a number of additional functional properties that may contribute to their beneficial influence on the arterial wall. A number of exciting therapeutic strategies have been developed that target HDL and its ability to protect against the development of atherosclerotic plaque. This paper will review how the promotion of the functional properties of HDL inhibits the formation of atherosclerotic plaque and stabilises lesions in patients with established disease.

Cell Research (2006) 16:799-808. doi:10.1038/sj.cr.7310097; published online 3 October 2006

Keywords: high-density lipoproteins, cardiovascular disease, atherosclerotic plaque, stabilises lesions