REVIEW

Cell Research (2006)16: 162-168
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Insight into the biology of Macrophage Migration Inhibitory Factor (MIF)revealed by the cloning of its cell surface receptor

Lin Leng¹, Richard Bucala¹

¹Departments of Medicine and Pathology, Yale University School of Medicine, The Anlyan Center, S525, 300 Cedar Street, New Haven CT 06520-8056, USA

Correspondence: Lin Leng E-mail:Lin.Leng@Yale.edu

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The recent cloning of MIF receptor fills an important gap in our understanding of the molecular biology and immunology of MIF. The MIF receptor, like MIF, does not fall into any established family of protein mediators, providing both new challenges and opportunities for the structural and functional analysis of MIF signal transduction.

Cell Research (2006) 16:162-168. doi:10.1038/sj.cr.7310022; published online 13 February 2006

Keywords: MIF, MIF receptor, ERK-1/2