REVIEW

Cell Research (2006)16:196-202
© 2006 IBCB, SIBS, CAS All rights reserved 1001-0602/06 $ 30.00
www.nature.com/cr

Regulation of cytokine signaling pathways by PIAS proteins

Ke Shuai¹

¹Division of Hematology-Oncology, Department of Medicine; Department of Biological Chemistry, University of California Los Angeles, Los Angeles, California 90095, USA

Correspondence: Ke Shuai Division of Hematology/Oncology, 11-934 Factor Bldg, 10833 Le Conte Avenue, Los Angeles, California 90095-1678, USA Tel: 310-206-9168; Fax: 310-825-2493; E-mail:kshuai@mednet.ucla.edu

Table of Contents Download as printable (PDF) file Full Text (html)file Search Medline for articles by: Ke Shuai

Cytokines activate multiple signal transduction pathways to regulate gene expression. STATs and NF-kB are two important families of transcription factors activated by cytokines. Abnormal regulation of STAT and NF-kB activities has been associated with human diseases. The protein inhibitor of activated STAT (PIAS) protein family has been proposed to interact with over 60 proteins, many of which are transcription factors involved in the immune system. PIAS proteins regulate transcription through several mechanisms, including blocking the DNA-binding activity of transcription factors, recruiting transcriptional co-repressors and promoting protein sumoylation. This article is to review the role of PIAS proteins in the regulation of STAT and NF-kB signaling pathways.

Cell Research (2006) 16:196-202. doi:10.1038/sj.cr.7310027; published online 13 February 2006

Keywords: cytokine signaling, gene regulation, PIAS, STAT, NF-κB