REVIEW

Cell Research (2006)16:214-219
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STAT3 in immune responses and inflammatory bowel diseases

Xin Yuan Fu¹

¹Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, 635 Barnhill Drive, MS 420, Indianapolis, IN 46202-5120, USA

Correspondence: Xin Yuan Fu Tel: 317-274-2082; Fax: 317-274-4090; E-mail: xfu@IUPUI.edu

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STAT3 has been known as a mediator for gene expression induced by many important cytokines. Recent studies have suggested that STAT3 has important functions in regulation of both innate and adaptive immunity. Loss of STAT3 in immune cells caused severe inflammation in response to pathogens. This review discusses the recent progress and suggests directions for the future research on this interesting molecule.

Cell Research (2006) 16:214-219. doi:10.1038/sj.cr.7310029; published online 13 February 2006

Keywords: STAT, cytokines, innate and adaptive immunity, Inflammation, Crohn’s disease, autoimmunity