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Cell Research (2006)16: 713-722
© 2006 IBCB, SIBS, CAS All rights reserved 1001-0602/06 $ 30.00
www.nature.com/cr

Skeletal myogenesis by human embryonic stem cells

Jun Ke Zheng, Yi Wang, Aditi Karandikar, Qian Wang, Hui Gai, Ai Lian Liu, Chao Peng, Hui Zhen Sheng,

¹Center for Developmental Biology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, 1665 Kong Jiang Road, Shanghai 200092, China; 2Laboratory of Stem Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China

Correspondence: Hui Zhen Sheng
Tel/Fax: +86-21-55570017;
E-mail: hzsheng2003@yahoo.com
Received 27 Jan 2006; revised 11 May 2006; accepted 26 May 2006; published
online 20 Jun 2006

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Hui Zhen Sheng

We have examined the myogenic potential of human embryonic stem (hES) cells in a xeno-transplantation animal model. Here we show that precursors differentiated from hES cells can undergo myogenesis in an adult environment and give rise to a range of cell types in the myogenic lineage. This study provides direct evidences that hES cells can regenerate both muscle and satellite cells in vivo and are another promising cell type for treating muscle degenerative disorders in addition to other myogenic cell types.

Cell Research (2006) 16:713-722. doi:10.1038/sj.cr.7310080; published online 20 June 2006

Keywords: Skeletal myogenesis, embryonic stem cell, differentiation

ISSN:1001-0602(Print),1748-7838(Online);CN:31-1568

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