REVIEW

Cell Research (2007): 89-99
© 2007 IBCB, SIBS, CAS All rights reserved 1001-0602/06 $ 30.00
www.nature.com/cr

Monoclonal antibodies as therapeutic agents in oncology and antibody gene therapy

Qi Zhang1, Guihua Chen1, Xinyuan Liu2, Qijun Qian3

1Transplantation Research Institute of Sun Yat-sen University, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou 510630, China; 2Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China; 3Laboratory of Viral and Gene Therapy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 225 Changhai Rd, Shanghai 200438, China

Correspondence: Qijun Qian
Tel: +86-21-35030677; Fax: +86-21-35030677;
E-mail: qianqj@sino-gene.cn

Antibodies as therapeutic agents are mostly used in oncology, as illustrated by their applications in lymphoma, breast cancer or colorectal cancer. This review provides a brief historical sketch of the development of monoclonal antibodies for cancer treatment and summarizes the most significant clinical data for the best-established reagents to date. It also discusses strategies to improve the anti-tumor efficacy of antibody therapy, including antibody gene therapy and exploitation of bone marrow derived primary mesenchymal stem cells as the antibody gene transporter.

Cell Research (2007) 17:89-99. doi: 10.1038/sj.cr.7310143; published online 23 January 2007

Keywords: monoclonal antibody, cancer, gene therapy

 

copyright©2006 Institute of Biochemistry and Cell Biology,SIBS,CAS

  ISSN:1001-0602(Print),1748-7838(Online);CN:31-1568

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