REVIEW

Cell Research (2007): 486-511
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Fat poetry: a kingdom for PPARγ

Silvia I Anghel¹ and Walter Wahli¹

Correspondence: Walter Wahli Tel: +41-21-692-4110; Fax: +41-21-692-4115 E-mail: walter.wahli@unil.ch

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Adipose tissue is not an inert cell mass contributing only to the storage of fat, but a sophisticated ensemble of cellular components with highly specialized and complex functions. In addition to managing the most important energy reserve of the body, it secretes a multitude of soluble proteins called adipokines, which have beneficial or, alternatively, deleterious effects on the homeostasis of the whole body. The expression of these adipokines is an integrated response to various signals received from many organs, which depends heavily on the integrity and physiological status of the adipose tissue. One of the main regulators of gene expression in fat is the transcription factor peroxisome proliferator-activated receptor γ (PPARγ), which is a fatty acid- and eicosanoid-dependent nuclear receptor that plays key roles in the development and maintenance of the adipose tissue. Furthermore, synthetic PPARγ agonists are therapeutic agents used in the treatment of type 2 diabetes.

This review discusses recent knowledge on the link between fat physiology and metabolic diseases, and the roles of PPARγ in this interplay via the regulation of lipid and glucose metabolism. Finally, we assess the putative benefits of targeting this nuclear receptor with still-to-be-identified highly selective PPARγ modulators.

Cell Research (2007) 17:486–511. doi: 10.1038/cr.2007.48; published online 12 June 2007

Keywords: adipose tissue, energy homeostasis, obesity, peroxisome proliferator-activated receptor