REVIEW

Cell Research (2007): 581-590
© 2007 IBCB, SIBS, CAS All rights reserved 1001-0602/06 $ 30.00
www.nature.com/cr

Systems perspectives on mRNA processing

Adrienne E McKee and Pamela A Silver

Correspondence: Pamela A Silver E-mail: pamela_silver@hms.harvard.edu

Download as printable (PDF) file Full Text (html)file Search Medline for articles by: Adrienne E McKee

The application of genomic technologies to the study of mRNA processing is increasingly conducted in metazoan organisms in order to understand the complex events that occur during and after transcription. Large-scale systems analyses of mRNA-protein interactions and mRNA dynamics have revealed specificity in mRNA transcription, splicing, transport, translation, and turnover, and have begun to make connections between the different layers of mRNA processing. Here, we review global studies of post-transcriptional processes and discuss the challenges facing our understanding of mRNA regulation in metazoan organisms. In parallel, we examine genome-scale investigations that have expanded our knowledge of RNA-binding proteins and the networks of mRNAs that they regulate.

Cell Research (2007) 17:581-590. doi: 10.1038/cr.2007.54; published online 10 July 2007

Keywords: RNA-binding protein, post-transcriptional regulation, systems biology, functional genomics