REVIEW

Cell Research (2008): 716-724
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Mapping the human protein interactome

Daniel Figeys

Correspondence: Daniel Figeys dfigeys@uottawa.ca

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Interactions are the essence of all biomolecules because they cannot fulfill their roles without interacting with other molecules. Hence, mapping the interactions of biomolecules can be useful for understanding their roles and functions. Furthermore, the development of molecular based systems biology requires an understanding of the biomolecular interactions. In recent years, the mapping of protein-protein interactions in different species has been reported, but few reports have focused on the large-scale mapping of protein-protein interactions in human. Here, we review the developments in protein interaction mapping and we discuss issues and strategies for the mapping of the human protein interactome.

Cell Research (2008) 18:716–724. doi: 10.1038/cr.2008.72; published online 24 June 2008

Keywords: interactome, protein interaction, yeast two hybrid, immunopurification, mass spectrometry, LUMIER, co-localization