REVIEW

Cell Research (2010): 124-137
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PPARs: diverse regulators in energy metabolism and metabolic diseases

Yong-Xu Wang

Program in Gene Function and Expression and Program in Molecular Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA

Correspondence: Yong-Xu Wang,
Tel: +1-508-856-5647
E-mail: yongxu.wang@umassmed.edu

The nuclear receptor PPARs are fundamentally important for energy homeostasis. Through their distinct yet overlapping functions and tissue distribution, the PPARs regulate many aspects of energy metabolism at the transcriptional level. Functional impairment or dysregulation of these receptors leads to a variety of metabolic diseases, while their ligands offer many metabolic benefits. Studies of these receptors have advanced our knowledge of the transcriptional basis of energy metabolism and helped us understand the pathogenic mechanisms of metabolic syndrome.

Cell Research (2010) 20:124–137. doi: 10.1038/cr.2010.13; published online 26 January 2010

Keywords: PPAR, transcriptional regulation, energy metabolism, metabolic diseases, fatty acid metabolism, obesity, insulin resistance

 

 

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