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Adaptation to MOMP drives cancer persistence
Emma Guilbaud1 , Lorenzo Galluzzi1,2,3,*
1Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USAWhile widespread mitochondrial outer membrane permeabilization (MOMP) generally seals the fate of stressed cancer cells as it elicits caspase-dependent mechanisms that regulate the kinetics and immunological manifestations of cell death, partial MOMP driving sublethal caspase activation has been associated with cancer cell survival in the context of accrued genomic instability. Recent findings delineate a novel caspase-independent mechanism linking sublethal MOMP to the acquisition of a persister phenotype coupled to chemoresistance and accrued metastatic potential.
https://doi.org/10.1038/s41422-022-00729-4