Advanced Search

Submit Manuscript

ADVANCE ONLINE PUBLICATION

RESEARCH HIGHLIGHTS

Adaptation to MOMP drives cancer persistence

Emma Guilbaud1 , Lorenzo Galluzzi1,2,3,*

1Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA
2Sandra and Edward Meyer Cancer Center, New York, NY, USA
3Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA
* Correspondence: Lorenzo Galluzzi(deadoc80@gmail.com)

While widespread mitochondrial outer membrane permeabilization (MOMP) generally seals the fate of stressed cancer cells as it elicits caspase-dependent mechanisms that regulate the kinetics and immunological manifestations of cell death, partial MOMP driving sublethal caspase activation has been associated with cancer cell survival in the context of accrued genomic instability. Recent findings delineate a novel caspase-independent mechanism linking sublethal MOMP to the acquisition of a persister phenotype coupled to chemoresistance and accrued metastatic potential.

https://doi.org/10.1038/s41422-022-00729-4

FULL TEXT | PDF

Browse 279