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mTOR gets greasy: lysosomal sensing of cholesterol
Liron Bar-Peled1,* , Dudley W. Lamming2,3,*
1MGH Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USAThe mechanistic Target of Rapamycin Complex 1 (mTORC1) regulates diverse metabolic processes in response to nutrient stimuli and environmental cues. In a recent issue of Science, Shin et al. report the identification of a lysosomal G protein-coupled receptor-like protein that binds to cholesterol and couples the availability of this critical macronutrient to mTORC1 activation.
https://doi.org/10.1038/s41422-022-00740-9