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Objection non-responsive! How maternal immune activation in pregnancy weakens subsequent microglial immune response

Thomas Blank^1,* , Marco Prinz^1,2,3,*

¹Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany
²Center for NeuroModulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany
³Signalling Research Centers BIOSS and CIBSS, University of Freiburg, Freiburg, Germany
* Correspondence: Thomas Blank(thomas.blank@uniklinik-freiburg.de)Marco Prinz(marco.prinz@uniklinik-freiburg.de)

Virus-like immunological stress during pregnancy diminishes subsequent microglia reactivity, elevating astrocyte inflammatory state and reducing synaptic activity in medium spiny neurons of the ventral striatum.

https://doi.org/10.1038/s41422-022-00756-1

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