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tRNA-m¹A modification: a translational checkpoint for T cell expansion

Weike Pei^1,2,* , Vijay K. Kuchroo^3,4,*

¹Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China
²School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China
³Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA
⁴Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
* Correspondence: Weike Pei(peiweike@westlake.edu.cn)Vijay K. Kuchroo(vkuchroo@evergrande.hms.harvard.edu)

As the major effector cells for protecting the host from pathogens, T cells are required to meet massive demands of proteins to expand themselves quickly upon activation. In a recent paper published in Nature Immunology, Liu et al. reported that the m1A modification of transfer RNA can promote CD4+ T cell proliferation by enhancing the translation efficiency of a specific group of messenger RNAs, providing a new mechanism of translational control of T cell expansion.

https://doi.org/10.1038/s41422-022-00764-1

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