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Death receptor 5 rises to the occasion

Lixin Zheng^1,2,* , Yikun Yao^1,2,* , Michael J. Lenardo^1,2,*

¹Molecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
²Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
* Correspondence: Lixin Zheng(lizheng@nih.gov)Yikun Yao(yikun.yao@nih.gov)Michael J. Lenardo(lenardo@nih.gov)

Death receptors (DRs), mediate death and inflammation in many cell types, especially in the immune system. In a study published in Cell Research , Du et al. present new structures of lipid membrane-anchored DR5 ectodomains (ECDs) leading to a new model of self-associated DR5 ECDs lying horizontal to the membrane prior to ligand engagement, termed pre-ligand self-association.

https://doi.org/10.1038/s41422-022-00772-1

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