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Life mimics art
Muthukumaran Venkatachalapathy1 , Craig M. Crews1,2,3,*
1Department of Molecular, Cellular & Developmental Biology, Yale University, New Haven, CT, USAIchikawa et al. have discovered that C-terminal cyclic imides imitate the chemical motif of molecular glue degrader thalidomide and act as a naturally occurring degron of the E3 ligase cereblon.
https://doi.org/10.1038/s41422-022-00765-0