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Life mimics art

Muthukumaran Venkatachalapathy1 , Craig M. Crews1,2,3,*

1Department of Molecular, Cellular & Developmental Biology, Yale University, New Haven, CT, USA
2Department of Pharmacology, Yale University, New Haven, CT, USA
3Department of Chemistry, Yale University, New Haven, CT, USA
* Correspondence: Craig M. Crews(craig.crews@yale.edu)

Ichikawa et al. have discovered that C-terminal cyclic imides imitate the chemical motif of molecular glue degrader thalidomide and act as a naturally occurring degron of the E3 ligase cereblon.

https://doi.org/10.1038/s41422-022-00765-0

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