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Mitochondrial PD-L1 modulates cancer immunotherapy

Xiaoming Dai^1,† , Jing Liu^1,† , Wenyi Wei^1,*

¹Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
^†These authors contributed equally: Xiaoming Dai, Jing Liu
* Correspondence: Wenyi Wei(wwei2@bidmc.harvard.edu)

The expression and subcellular localization of immune checkpoint protein PD-L1 have been implicated to play an important role in cancer immunotherapy. In a recent paper published in Cell Research, Xie et al. report that promoting mitochondrial distribution of PD-L1 through targeting the ATAD3A-PINK1-mitophagy axis is a promising strategy to overcome chemoimmunotherapy resistance.

https://doi.org/10.1038/s41422-023-00777-4

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