ISSN: 1001-0602
EISSN: 1748-7838
2016 impact factor 15.606*
(Clarivate Analytics, 2017)
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  ADVANCE ONLINE PUBLICATION
 
  5 Jan 2018
  22 Dec 2017
  15 Dec 2017
  8 Dec 2017
  1 Dec 2017
  28 Nov 2017
  17 Nov 2017
  14 Nov 2017
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  15 Aug 2017
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  16 Sep 2016
  2 Sep 2016
  12 Aug 2016
  27 May 2016
  1 Mar 2016
  14 Jul 2015
  2 Jun 2015
  26 May 2015
  10 Apr 2012
  6 Dec 2011
  5 Jan 2018
LETTERS TO THE EDITOR
m6 A mRNA methylation sustains Treg suppressive functions
Jiyu Tong1,2,*, Guangchao Cao2,3,*, Ting Zhang1,*,Esen Sefik2, Maria Carolina Amezcua Vesely2,James P Broughton6, Shu Zhu4, Huabin Li5, Bin Li1, Lei Chen1, Howard Y Chang6, Bing Su1,2,Richard A Flavell2,7, Hua-Bing Li1,2
  22 Dec 2017
ORIGINAL ARTICLES
Cryo-EM structure of human ATR-ATRIP complex
Qinhui Rao1,2,3,*, Mengjie Liu1,2,3,*, Yuan Tian1,2,3, Zihan Wu1,2,3, Yuhan Hao1,2,3, Lei Song4, Zhaoyu Qin1, Chen Ding1,3, Hong-Wei Wang5, Jiawei Wang5, Yanhui Xu1,2,3,6
  15 Dec 2017
LETTERS TO THE EDITOR
Chemically synthesized histone H2A Lys13 di-ubiquitination promotes binding of 53BP1 to nucleosomes
Jia-Bin Li1, *, Yun-Kun Qi2, 3, *, Qiao-Qiao He2,Hua-Song Ai2, San-ling Liu1, Jia-Xing Wang2,Ji-Shen Zheng1, Lei Liu2, Changlin Tian1
  8 Dec 2017
RESEARCH HIGHLIGHTS
New traffic light on Th17 Avenue
Hao Xu1, Dan R Littman1, 2
REVIEWS
Mitochondrial metabolism and cancer
Paolo Ettore Porporato1, *, Nicoletta Filigheddu2, *, Jose Manuel Bravo-San Pedro3, 4, 5, 6, 7, Guido Kroemer3, 4, 5, 6, 7, 8, 9, Lorenzo Galluzzi3, 10, 11
  1 Dec 2017
RESEARCH HIGHLIGHTS
Wild gut microbiota protect from disease
Francesca S Gazzaniga1 ,Dennis L Kasper1
Portending death in germinal centers — when B cells know their time is up
Lili Wang1, Markus Müschen1
TRFH domain: at the root of telomere protein evolution?
Marie-Joseph Giraud-Panis1, Jing Ye2, Eric Gilson1, 2, 3
Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway
He Huang, Zhouqing Luo, Shankang Qi, Jing Huang, Peng Xu, Xiuxuan Wang, Li Gao, Fangyi Li, Jian Wang, Wenhui Zhao, Wei Gu, Zhucheng Chen, Lunzhi Dai, Junbiao Dai & Yingming Zhao
GOTcha: lncRNA-ACOD1 targets metabolism during viral infection
Marah C Runtsch1, Luke AJ O’Neill1
Avian influenza H7N9 viruses: a rare second warning
Kanta Subbarao1
  28 Nov 2017
ORIGINAL ARTICLES
Structural basis for specific flagellin recognition by the NLR protein NAIP5
Xinru Yang1,2,*, Fan Yang3,*, Weiguang Wang1,*, Guangzhong Lin1,2,*, Zehan Hu1,2,*, Zhifu Han1,2, Yijun Qi2,
Liman Zhang4, Jiawei Wang1, Sen-Fang Sui3, Jijie Chai1,2,5,6
  17 Nov 2017
ORIGINAL ARTICLES
Integrated genomic analysis identifies deregulated JAK/STAT-MYC biosynthesis axis in aggressive NK-cell leukemia
Liang Huang1,*, Dan Liu2,*, Na Wang1,*, Shaoping Ling2,17,*, Yuting Tang1,*, Jun Wu2, Lingtong Hao2,5,17, Hui Luo1, Xuelian Hu1, Lingshuang Sheng1, Lijun Zhu1, Di Wang1, Yi Luo1, Zhen Shang1, Min Xiao1, Xia Mao1,Kuangguo Zhou1, Lihua Cao2,17, Lili Dong2, Xinchang Zheng2,5, Pinpin Sui2,5, Jianlin He2, Shanlan Mo2,5, Jin Yan2, Qilin Ao3, Lugui Qiu4, Hongsheng Zhou6, Qifa Liu6, Hongyu Zhang7, Jianyong Li8, Jie Jin9, Li Fu10,Weili Zhao11, Jieping Chen12, Xin Du13, Guoliang Qing14, Hudan Liu14, Xin Liu2,5, Gang Huang15,16, Ding Ma18,19,Jianfeng Zhou1,4,19, Qian-fei Wang2,4,5
RESEARCH HIGHLIGHTS
PRRT2-dependent dyskinesia: cerebellar, paroxysmal and persisten
Lieke Kros1, Chris I De Zeeuw1,2
LETTERS TO THE EDITOR
Endothelial-specific m6A modulates mouse hematopoietic stem and progenitor cell development via Notch signaling
Junhua Lv1,4,*, Yifan Zhang1,4,*, Suwei Gao1,5,*, Chunxia Zhang1,4,*, Yusheng Chen3,4,*, Wei Li2,4, Yun-Gui Yang3,4, Qi Zhou2,4, Feng Liu1,4
  14 Nov 2017
LETTERS TO THE EDITOR
The 11th C2H2 zinc finger and an adjacent C-terminal arm are responsible for TZAP recognition of telomeric DNA
Yaqing Zhao, Guang Zhang, Chao He, Yide Mei, Yunyu Shi & Fudong Li
  10 Nov 2017
ORIGINAL ARTICLES
Mouse embryonic stem cells have increased capacity for replication fork restart driven by the specific Filia-Floped protein complex
Bo Zhao1,2,*, Weidao Zhang1,2,3,*, Yixian Cun1, Jingzheng Li1,2,3, Yan Liu1,2, Jing Gao4, Hongwen Zhu4,Hu Zhou4, Rugang Zhang5, Ping Zheng1,
  3 Nov 2017
LETTERS TO THE EDITOR
Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis OPEN
Xuepeng Wang1,2,*, Tianda Li1,*, Tongtong Cui1,2,*, Dawei Yu1,*, Chao Liu1,2,*, Liyuan Jiang1,3, Guihai Feng1, Lei Wang1,2, Rui Fu1, Xinxin Zhang1,3, Jie Hao1, Yukai Wang1, Liu Wang1,2, Qi Zhou1,2, Wei Li1,2 and Baoyang Hu1,2
  31 Oct 2017
ORIGINAL ARTICLES
Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior OPEN
Suyan Li1,2,*, Peeyush Kumar T1,2,*, Sampada Joshee2, Timo Kirschstein3, Sivan Subburaju1,4, Jahan S Khalili5, Jonas Kloepper6, Chuang Du7, Abdallah Elkhal8,9, Gábor Szabó10, Rakesh K Jain6, Rüdiger Köhling3 and Anju Vasudevan1,2
  27 Oct 2017
REVIEWS
Plasma membrane changes during programmed cell deaths OPEN
Yingying Zhang1, Xin Chen1, Cyril Gueydan2 and Jiahuai Han1
ORIGINAL ARTICLES
Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders
Xingxing Xu1,*, Chuanyin Li1,2,*, Xiaobo Gao1,2,*, Kun Xia3,*, Hui Guo3, Yali Li1, Zijian Hao1,2, Lei Zhang1, Daming Gao1, Chenfan Xu1, Huatai Xu4, Zhi-Qi Xiong4, Zilong Qiu4, Ling Mei5, Xiaoduo Xie1, Kangcheng Ruan1 and Ronggui Hu1
Derivation of hypermethylated pluripotent embryonic stem cells with high potency OPEN
Siqin Bao1,2, Walfred WC Tang3, Baojiang Wu2, Shinseog Kim3,8, Jingyun Li4, Lin Li4, Toshihiro Kobayashi3, Caroline Lee3, Yanglin Chen2, Mengyi Wei2, Shudong Li5, Sabine Dietmann6, Fuchou Tang4, Xihe Li1,2,7 and M Azim Surani3
  20 Oct 2017
ORIGINAL ARTICLES
PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum OPEN
Guo-He Tan1,2,*, Yuan-Yuan Liu1,*, Lu Wang1,*, Kui Li1,*, Ze-Qiang Zhang1,3, Hong-Fu Li4, Zhong-Fei Yang1, Yang Li1, Dan Li1, Ming-Yue Wu1, Chun-Lei Yu5, Juan-Juan Long6, Ren-Chao Chen1, Li-Xi Li4, Lu-Ping Yin1, Ji-Wei Liu1, Xue-Wen Cheng1, Qi Shen1, You-Sheng Shu1, Kenji Sakimura7, Lu-Jian Liao5,#, Zhi-Ying Wu4,# and Zhi-Qi Xiong1,3
  15 Aug 2017
ORIGINAL ARTICLES
Ythdc2 is an N 6-methyladenosine binding protein that regulates mammalian spermatogenesis
Phillip J Hsu1,2,3,*, Yunfei Zhu4,*, Honghui Ma1,2,*, Yueshuai Guo4,*, Xiaodan Shi4, Yuanyuan Liu4, Meijie Qi4, Zhike Lu1,2, Hailing Shi1,2, Jianying Wang4, Yiwei Cheng4, Guanzheng Luo1,2, Qing Dai1,2, Mingxi Liu4, Xuejiang Guo4, Jiahao Sha4, Bin Shen4 and Chuan He1,2,5
  2 Jun 2017
RESEARCH HIGHLIGHTS
Novel ubiquitin cleavage: The DUB blade goes snicker-snack FREE
Judith A Ronau1 and Mark Hochstrasser1,2
  21 Apr 2017
RESEARCH HIGHLIGHTS
Beyond growth signaling: Paneth cells metabolically suppport ISCs FREE
Talya L Dayton1 and Hans Clevers1
  28 Feb 2017
ORIGINAL ARTICLES
New evidence for non-canonical Hippo signaling in cancer FREE
Jonathan Cooper1 and Filippo G Giancotti2
  10 Feb 2017
RESEARCH HIGHLIGHTS
Both sides of the same coin: Rac1 alternative splicing by EGF signaling FREE
Xiang-Dong Fu1
  20 Jan 2017
LETTERS TO THE EDITOR
Simultaneous enhancement of cellular and humoral immunity by the high salt formulation of Al(OH)3 adjuvant
Min Luo1,*, Bin Shao1,*, Jia-yun Yu1,*, Ting Liu1, Xiao Liang1, Lian Lu1, Ting-hong Ye1, Zhi-yao He1, Heng-yi Xiao1 and Xia-wei Wei1
  16 Sep 2016
LETTERS TO THE EDITOR
Artemisinin derivatives prevent obesity by inducing browning of WAT and enhancing BAT function FREE
Ping Lu1, Fu-chuang Zhang2, Shu-wen Qian1, Xi Li1, Zhao-meng Cui1, Yong-jun Dang1 and Qi-qun Tang1,2
  2 Sep 2016
LETTERS TO THE EDITOR
A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses OPEN
Jiuyu Wang1,2,*, Jun Ma3,4,*, Zhi Cheng1,2, Xu Meng1,5, Lilan You1,2,6, Min Wang1,2, Xinzheng Zhang3,4 and Yanli Wang1,2,6
  12 Aug 2016
RESEARCH HIGHLIGHTS
Closing the gap between astrocytes and brain metastasis progression FREE
Gino B Ferraro1, David P Kodack1, Vasileios Askoxylakis1 and Rakesh K Jain1
  27 May 2016
RESEARCH HIGHLIGHTS
How tumor cells cope with the metabolic stress of leaving home FREE
Jonathan L Coloff1 and Joan S Brugge1
  1 Mar 2016
RESEARCH HIGHLIGHTS
CRISPR/Cas9 treatment for Duchenne muscular dystrophy FREE
Jerry R Mendell1,2,3 and Louise R Rodino-Klapac1,2,3
  14 Jul 2015
RESEARCH HIGHLIGHTS
Controlling the diversity of cell populations in a stem cell culture FREE
Inha Heo1 and Hans Clevers1
  2 Jun 2015
RESEARCH HIGHLIGHTS
Targeted genome editing in primate embryos FREE
Xiangyu Guo1 and Xiao-Jiang Li1,2
  26 May 2015
RESEARCH HIGHLIGHTS
Innate and adaptive immunity join forces to promote metastatic spread FREE
Zvi G Fridlender1, Steven M Albelda2 and Zvi Granot3
  10 Apr 2012
RETRACTION
Retraction: Defective heart development in hypomorphic LSD1 mice
Thomas B Nicholson, Hui Su, Sarah Hevi, Jing Wang, Jeff Bajko, Mei Li, Reginald Valdez, Joseph Loureiro, Xiaodong Cheng, En Li, Bernd Kinzel, Mark Labow and Taiping Chen
  6 Dec 2011
ORIGINAL ARTICLES
Defective heart development in hypomorphic LSD1 mice
Thomas B Nicholson1,2, Hui Su1,2, Sarah Hevi1,2, Jing Wang2, Jeff Bajko2, Mei Li1, Reginald Valdez1, Joseph Loureiro1, Xiaodong Cheng3, En Li2, Bernd Kinzel4, Mark Labow1 and Taiping Chen1,2,5

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