ISSN: 1001-0602
EISSN: 1748-7838
2012 impact factor 10.526*
(Thomson Reuters, 2013)
Free Sample Issue
 

VOLUME 27 ISSUE 8(8,2017): 963-964

 

Repolarizing macrophages improves breast cancer therapy FREE

 

Luca Cassetta1 and Jeffrey W Pollard1,2

 

1MRC Centre for Reproductive Health, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK
2Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York 10461, USA

Correspondence:Jeffrey W Pollard,        

E-mail: Jeff.Pollard@ed.ac.uk

 

Tumor-associated macrophages (TAMs) contribute to breast cancer progression and dissemination; TAM-targeting strategies aimed at their reprogramming show promising preclinical results. In a new report Guerriero and colleagues demonstrate that a novel HDAC Class IIa inhibitor, TMP195, can reprogram monocytes and macrophages in the tumor into cells able to sustain a robust CD8 T cell-mediated anti-tumoral immune response.

 

10.1038/cr.2017.63

 
 
Browse  662

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.
 
Home | Resources | Jobs | Contact Us
Copyright © 2013-2015 Institute of Biochemistry and Cell Biology, SIBS, CAS
您是第 位访问者,欢迎!
 沪ICP备05033115号