ISSN: 1001-0602
EISSN: 1748-7838
2012 impact factor 10.526*
(Thomson Reuters, 2013)
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VOLUME 27 ISSUE 8(8,2017): 963-964


Repolarizing macrophages improves breast cancer therapy FREE


Luca Cassetta1 and Jeffrey W Pollard1,2


1MRC Centre for Reproductive Health, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK
2Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York 10461, USA

Correspondence:Jeffrey W Pollard,        



Tumor-associated macrophages (TAMs) contribute to breast cancer progression and dissemination; TAM-targeting strategies aimed at their reprogramming show promising preclinical results. In a new report Guerriero and colleagues demonstrate that a novel HDAC Class IIa inhibitor, TMP195, can reprogram monocytes and macrophages in the tumor into cells able to sustain a robust CD8 T cell-mediated anti-tumoral immune response.



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