ISSN: 1001-0602
EISSN: 1748-7838
2012 impact factor 10.526*
(Thomson Reuters, 2013)
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VOLUME 27 ISSUE 8(8,2017): 1069-1072


Polar bodies are efficient donors for reconstruction of human embryos for potential mitochondrial replacement therapy


Keliang Wu1,2,3,*, Cuiqing Zhong1,2,3,4,5,6,*, Tailai Chen1,2,3,*, Xiaoyu Zhang6, Wenrong Tao1,2,3, Jingye Zhang1,2,3, Hongchang Li1,2,3, Han Zhao1,2,3, Jinsong Li6,7 and Zi-Jiang Chen1,2,3,4,5


1Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250001, China
2National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, Shandong 250001, China
3The Key laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, Shandong 250001, China
4Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, China
5Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai 200135, China
6State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences & University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
7School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai 201210, China

Correspondence:Zi-Jiang Chen, E-mail:; Jinsong Li, E-mail:; Han Zhao,        



In mice, the first (1st) and second (2nd) polar bodies (PBs) can be used in place of the female genome of oocytes or zygotes and efficiently support the generation of embryonic stem cells (ESCs) and normal offspring1,2,3. These results indicate that both 1st and 2nd PBs can be used as nuclear donors for mitochondrial replacement therapy (MRT)4, which is an effective approach for preventing the transmission of disease-causing mutant mitochondria from mother to children5.



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