ISSN: 1001-0602
EISSN: 1748-7838
2012 impact factor 10.526*
(Thomson Reuters, 2013)
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VOLUME 28 ISSUE 10(10,2018): 967-968


cGAS activation in phased droplets


Yongbo Liu 1, Hua-Bing Li 1 and Richard A. Flavell 2,3


1Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China; 2Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520-8055, USA and 3Howard Hughes Medical Institute, Chevy Chase, MD 20815-6789, USA

Correspondence:Correspondence: H-B. Li ( or Richard A. Flavell (        


Cyclic GMP-AMP synthase (cGAS) is activated by DNA through direct binding. Active cGAS catalyzes the production of cyclic GMP-AMP (cGAMP), and consequently activates the innate immune responses. However, the detailed biological processes are poorly understood. Du and Chen demonstrated in a recent paper published on Science that DNA binding to cGAS robustly induced the formation of liquid like droplets in which cGAS was activated.

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