ISSN: 1001-0602
EISSN: 1748-7838
2012 impact factor 10.526*
(Thomson Reuters, 2013)
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VOLUME 29 ISSUE 8(8,2019): 601-602


pH-sensitive anti-CTLA4 antibodies: yes to efficacy, no to toxicity


Amnon Altman 1 and Kok-Fai Kong 1


1Division of Cell Biology, La Jolla Institute for Immunology, La Jolla, CA 92037, USA

Correspondence:Amnon Altman (        


For a long time, anti-CTLA-4 antibodies were believed to mediate their beneficial cancer immunotherapeutic effect (CITE), whose effectiveness and safety are limited by associated immune-related adverse effects (irAE), via blocking the interaction between CTLA-4 and its ligands, a mechanism known as checkpoint blockade. Using novel engineered antibodies, Zhang et al. challenge this paradigm in the present study, demonstrating that the irAE of anti-CTLA-4 antibodies can be uncoupled from their CITE, raising hopes for the design of a new generation of safer and more effective anti-CTLA-4 antibodies.

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