ISSN: 1001-0602
EISSN: 1748-7838
2012 impact factor 10.526*
(Thomson Reuters, 2013)
Free Sample Issue
 

VOLUME 29 ISSUE 8(8,2019): 603-604

 

Microbiota guides insulin trafficking in beta cells

 

Ozren Stojanović 1,2 and Mirko Trajkovski 1,2,3

 

1 Department of Cell Physiology and Metabolism, Faculty of Medicine, Centre Médical Universitaire, University of Geneva, 1211 Geneva, Switzerland; 2Diabetes Centre, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland and 3Institute of Genetics and Genomics in Geneva (IGE3), University of Geneva, 1211 Geneva, Switzerland

Correspondence:Mirko Trajkovski (Mirko.Trajkovski@unige.ch)
        

 

Pancreatic beta cells produce insulin on intricate cellular assembly line, but the extent of the gut microbiota involvement was not clear. It emerges that fragments of bacterial cell wall released by lysozyme 1 in the intestinal lumen are necessary to keep the machinery running, acting on the cytosolic peptidoglycan receptor Nod1 in the beta cells to regulate the insulin trafficking and glucose tolerance.

 

https://doi.org/10.1038/s41422-019-0200-5

 
 
Browse  184

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.
 
Home | Resources | Jobs | Contact Us
Copyright © 2013-2015 Institute of Biochemistry and Cell Biology, SIBS, CAS
您是第 位访问者,欢迎!
 沪ICP备05033115号