ISSN: 1001-0602
EISSN: 1748-7838
2012 impact factor 10.526*
(Thomson Reuters, 2013)
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VOLUME 29 ISSUE 8(8,2019): 603-604


Microbiota guides insulin trafficking in beta cells


Ozren Stojanović 1,2 and Mirko Trajkovski 1,2,3


1 Department of Cell Physiology and Metabolism, Faculty of Medicine, Centre Médical Universitaire, University of Geneva, 1211 Geneva, Switzerland; 2Diabetes Centre, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland and 3Institute of Genetics and Genomics in Geneva (IGE3), University of Geneva, 1211 Geneva, Switzerland

Correspondence:Mirko Trajkovski (


Pancreatic beta cells produce insulin on intricate cellular assembly line, but the extent of the gut microbiota involvement was not clear. It emerges that fragments of bacterial cell wall released by lysozyme 1 in the intestinal lumen are necessary to keep the machinery running, acting on the cytosolic peptidoglycan receptor Nod1 in the beta cells to regulate the insulin trafficking and glucose tolerance.

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