ISSN: 1001-0602
EISSN: 1748-7838
2012 impact factor 10.526*
(Thomson Reuters, 2013)
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VOLUME 29 ISSUE 8(8,2019): 605-606


Crystallizing BubR1’s kinase activity


Jazeel F. Limzerwala1 and Jan M. van Deursen 1,2


1 Departments of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA and 2Departments of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA

Correspondence:Jan M. van Deursen (        


BubR1 has been implicated in fundamental biological processes such as cell division, cancer, aging and age-related diseases, but whether this mitotic checkpoint protein acts as a kinase has remained a matter of intense debate. With a multi-pronged approach involving the use of structural biology, substrate identification, pharmacological inhibition of kinase activity, and functional assays, Huang et al. now provide compelling evidence that BubR1 has enzymatic activity.

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