ISSN: 1001-0602
EISSN: 1748-7838
2012 impact factor 10.526*
(Thomson Reuters, 2013)
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VOLUME 29 ISSUE 8(8,2019): 605-606

 

Crystallizing BubR1’s kinase activity

 

Jazeel F. Limzerwala1 and Jan M. van Deursen 1,2

 

1 Departments of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA and 2Departments of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA

Correspondence:Jan M. van Deursen (vandeursen.jan@mayo.edu)        

 

BubR1 has been implicated in fundamental biological processes such as cell division, cancer, aging and age-related diseases, but whether this mitotic checkpoint protein acts as a kinase has remained a matter of intense debate. With a multi-pronged approach involving the use of structural biology, substrate identification, pharmacological inhibition of kinase activity, and functional assays, Huang et al. now provide compelling evidence that BubR1 has enzymatic activity.

 

https://doi.org/10.1038/s41422-019-0199-7

 
 
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