ISSN: 1001-0602
EISSN: 1748-7838
2012 impact factor 10.526*
(Thomson Reuters, 2013)
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VOLUME 29 ISSUE 8(8,2019): 607-608


AIF: an acquired metabolic liability in lung cancer


Brandon Faubert1, Ralph J. DeBerardinis 1,2,3,4 and John D. Minna 5,6


1 Children’s Medical Center Research Institute, Dallas, TX, USA; 2Department of Pediatrics, Dallas, TX, USA; 3Eugene McDermott Center for Human Growth and Development, Dallas, TX, USA; 4Howard Hughes Medical Institute, Dallas, TX, USA; 5Hamon Center for Therapeutic Oncology Research, Dallas, TX, USA and 6Department of Internal Medicine and Simmons Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA

Correspondence:Brandon Faubert ( or Ralph J. DeBerardinis ( or John D. Minna


Apoptosis-inducing factor has two roles: acting as an apoptosis effector and maintaining mitochondrial metabolism. A recent study uncouples these roles and finds that only the mitochondrial functions are required for tumorigenesis in mice.

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