Gang PEI

Editor-in-Chief, Cell Research (2006- )

Professor of Institute of Biochemistry and Cell Biology, President of Shanghai Institutes for Biological Sciences,
Member, Division of Biology, Chinese Academy of Sciences.

Email: gpei@sibs.ac.cn

Education and Professional Experience:

Dr Gang Pei is a Professor and the President of Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS). He obtained his B.Sc. in Pharmacy in 1981 and M.Sc. in Pharmaceutical Sciences in 1984 from Shenyang College of Pharmacy, Shenyang, China. He then conducted research in the Department of Clinical Pharmacology, Karolinska Institute, Stockholm, Sweden as a visiting fellow in 1986. He subsequently obtained his Ph.D. in Biochemistry and Biophysics from University of North Carolina at Chapel Hill in 1991. Dr Pei undertook his post-doctoral training in Cell Biology and Signal Transduction at Duke University until he was recruited as a Research Group Leader at Shanghai Institute of Cell Biology, cosponsored by Chinese Academy of Sciences and the German Max-Planck Society in 1995.

Research Interest:

1) regulation of G protein-coupled receptor signaling and its role in epigenetics

2) crosstalk between distinct cellular signaling pathways

3) the molecular, cellular, and neural mechanisms of opiate addiction

4) the elucidation of the molecular mechanisms that underlie the efficacy of traditional Chinese medicine

Honors:

Dr Pei was elected to the Chinese Academy of Sciences in 1999 and the Third World Academy of Sciences (TWAS) in 2001. Currently, he serves as the president of Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) and the president of Chinese Society of Cell Biology (CSCB). Dr Pei jointed the Editorial Board of Cell Research as an Associate Editor-in-Chief in 2002, and he now succeeds Professor Zhen Yao as the Editor-in-Chief of Cell Research in Jan 2006.

Publications:

1 Wang Y, Tang Y, Teng L, Wu Y, Zhao X, Pei G. Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor- interleukin 1 receptor signaling. Nat Immunol 2005 Dec 25; [Epub ahead of print]

2 Kang J, Shi Y, Xiang B, Qu B, Su W, Zhu M, Zhang M, Bao G, Wang F, Zhang X, Yang R, Fan F, Chen X, Pei G, Ma L. A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. Cell 2005; 123:833-47.

3 Luan B, Zhang Z, Wu Y, Kang J, Pei G. Beta-arrestin2 functions as a ?phosphorylation-regulated suppressor of UV-induced NF-kappaB activation. EMBO J 2005; 24:4237-46.

4 Guan JS, Xu ZZ, Gao H, He SQ, Ma GQ, Sun T, Wang LH, Zhang ZN, Lena I, Kitchen I, Elde R, Zimmer A, He C, Pei G, Bao L, Zhang X. Interaction with vesicle luminal protachykinin regulates surface expression of delta-opioid receptors and opioid analgesia. Cell 2005; 122:619-31.

5 Xu NJ, Yu YX, Zhu JM, Liu H, Shen L, Zeng R, Zhang X, Pei G. Inhibition of SNAP-25 phosphorylation at Ser187 is involved in chronic morphine-induced downregulation of SNARE complex formation. J. Biol. Chem. 2004; 279:40601-8.

6 Gao H, Sun Y, Wu Y, Luan B, Wang Y, Qu B, Pei G. Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways. Mol. Cell 2004; 14:303-17.

7 Wang P, Gao H, Ni Y, Wang B, Wu Y, Ji L, Qin L, Ma L, Pei G. Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2. J Biol Chem 2003; 278:6363-70.

8 Xu NJ, Bao L, Fan HP, Bao GB, Pu L, Lu YJ, Wu CF, Zhang X, Pei G. Morphine withdrawal increases glutamate uptake and surface expression of glutamate transporter GLT1 at hippocampal synapses. J Neurosci 2003; 23:4775-84.

9 Wang P, Wu Y, Ge X, Ma L, Pei G. Subcellular localization of beta-arrestins is ?determined by their intact N domain and the nuclear export signal at the C terminus. J Biol Chem 2003; 278:11648-53.

10 Lu Pu, Guobin Bao, Nanjie Xu, Lan Ma, Gang Pei. Hippocampal LTP is Significantly Suppressed by Chronic Opiate Treatment and the Suppressed LTP can be Restored by Re-Exposure to Drugs. J. Neurosci. 2002; 22:1914-21.

11 Bo Cen, Ying Xiong, Lan Ma, and Gang Pei Direct and Differential Interaction of b-Arrestins with the Intracellular Domains of Different Opioid Receptors. Mol. Pharmacol. 2001; 59:758-764.

12 Nan-Jie Xu, Ling-Zhi Wang, Chun-Fu Wu, Gang Pei. Spatial learning and morphine-rewarded place preference negatively correlates in mice. Pharmacol. Biochem. Behavi. 2001; 68:389-94.

13 Bo Cen, Qijngming Yu, Jun Guo, Yalan Wu, Kun Ling, Zhijie Cheng, Lan Ma and Gang Pei. Direct binding of b-Arrestins to two distinct intracellular domains of delta opioid receptor. J. Neurochem. 2001; 76:1887-1894.

14 Bin Xiang, Guo-Hua Yu, Jun Guo, Li Chen, Wei Hu, Gang Pei and Lan Ma. Heterologous Activation of Protein Kinase C Stimulates Phosphorylation of b-Opioid Receptor at Serine 344, Resulting on ?-Arrestin-and Clathrin-mediated Receptor Internalization. J. Biol.Chem. 2001; 276:4709-4716

15 Jun Guo,Yalan Wu, Wenbo Zhang, Jing Zhao, Lakshmi A. Devi, Gang Pei, and LAN MA. Identification of G Protein-Coupled Receptor Kinase 2 Phosphorylation Sites Responsible for Agonist-Stimulated |?-Opioid Receptor Phosphorylation. Mol. Pharmacol. 2000; 58:1050-1056.

16 Qing Jing, Shun-Mei Xin, Wen-Bo Zhang, Ping Wang, Yong-Wen Qin, and Gang Pei. Lysophosphatidycholine Activates p38 and p42/44 Mitogen-Activated Protein Kinases in Monocytic THP-1 Cells, but Only p38 Activation Is Involved in Its Stimulated Chemotaxis. Cir. Res. 2000; 87:52-59.

17 Tian-Hua Zhou, Kun Ling, Jun Guo, Hui Zhou, Ya-Lan Wu, Qing Jing , Lan Ma , and Gang Pei. Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase. J. Biol. Chem. 2000; 275: 2513-9

18 Zhi-Jie Cheng, Jian Zhao , Yue Sun, Wei Hu , Ya-Lan Wu, Bo Cen , Guo-Xiang Wu, and Gang Pei. Beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4. J. Biol. Chem. 2000; 275: 2479-85

19 Lu Pu, Guobin Bao, Lan Ma, and Gang Pei. Acute desensitization of nociceptin/orphanin FQ inhibition of voltage-gated calcium channels in freshly dissociated hippocampal neurons. Euro. J. Neurosci. 1999; 11:3610-3616.

20 Hui Zhou, Xin Ge, Ling Zhi Wang, Lan Ma, and Gang Pei. Attenuation of morphine tolerance and dependence in scopolamine-treated rats. NeuroReport 1999; 10:2007-10.

21 Kun Ling, Ping Wang, Jian Zhao, Ya Lan Wu, Zhi Jie Cheng, Guo Xiang Wu, Wei Hu, Lan Ma, and Gang Pei. Five-transmembrane domains appear sufficient for a G protein-coupled receptor: Functional five-transmembrane domain chemokine receptors. Proc. Natl. Acad. Sci. 1999; 96:7922-7927.

22 Li Hong Ben, Jian Zhao, Shun-Mei Xin, Shen Qiu Luo, and Gang Pei. Attenuation of d opioid receptor-mediated signaling by kainic acid in neural cells: involvement of protein kinase C and Intracellular Ca2+. Neuropharmacol. 1999; 38: 991-998.

23 Guo Huang Fan, Ling Zhi Wang, Hao Chun Qiu, Lan Ma, and Gang Pei Inhibition of Calcium/Calmodulin-Dependent Protein Kinase II in Rat Hippocampus Attenuates Morphine Tolerance and Dependence. Mol. Pharmacol. 1999; 56:39-45.

24 Qing Jing, Shun Mei Xin, Zhi Jie Cheng, Wen Bo Zhang, Ru Zhang, Yong Wen Qin, and Gang Pei. Activation of p38 Mitogen-Activated Protein Kinase by Oxidized LDL in Vascular Smooth Muscle Cells Mediation via Pertussis Toxin-Sensitive G Protenins and Association With Oxidized LDL-Induced Cytotoxcity. Cir. Res. 1999; 84:831-839.

25 Li Guang Lou, Tian Hua Zhou, Ping Wang, and Gang Pei. Modulation of Ca2+/Calmodulin-Dependent Protein Kinase II Activity by Acute and Chronic Morphine Administration in Rat Hippocampus: Differential Regulation of alpha ?and beta Isoforms. Mol. Pharmacol. 1999; 55:557-563.

26 Zhi-Jie Cheng, Qing-Ming Yu, Ya-Lan Wu, Lan Ma, and Gang Pei. Selective Interference of beta-Arrestin 1 with kappa and delta but not mu Opioid Receptor/G Protein Coupling. J. Biol. Chem. 1998; 273: 24328-24333.

27 Guohuang Fan, Jing Zhao, Ya-Lan Wu, Zhe Zhang, Li-Guang Lou, Qing Jing, Lan Ma, and Gang Pei. N-methyl-D-aspartate attenuates opioid receptor-mediated G protein activation and this process involves protein kinase C. Mol. Pharmacol. 1998; 53: 684-690.

28 Li-Guang Lou, Zhe Zhang, Lan Ma, and Gang Pei. Nociceptin/Orphanin FQ activates mitogen-activated protein kinase in Chinese Hamster ovary cells expressing opioid receptor-like receptor. J. Neurochem. 1998; 70:316-1322.

29 Yingchun Cai, Lan Ma, Guohuang Fan, Jing Zhao, Lizhen Jiang and Gang Pei. Activation of N-methyl-D-aspartate receptor attenuates acute responsiveness of delta opioid receptor. Mol. Pharmacol. 1997; 51:583-587.

Cell Research Online (CRO) published bimonthly

suggested resolution 1024*768