Zhen YAO (Formerly T.Yao)

Founding Editor ( 1990-2005 )

Biography

Education:

B.S. in Biology, July 1937, Zhejiang University, Hangzhou, China.

Ph.D in Genetics, September 1949, Institute of Animal Genetics, Edinburgh, Scotland, U.K.

Professional Experience:

1937-1946: Assistant, Lecturer, Associate Professor, Department of Biology, Zhejiang University, Meitan, Guizhou, China ( with Prof. S. Pai ).

1946-1949: PhD Thesis: Cytochemical studies on the embryonic and post-embryonic development of Drosophila melanogaster (Supervisor: Prof. C.H.Waddington).

1950: Professor, Department of Biology, Zhejiang University, Hangzhou, China

1950-1978: Research Professor. Institute of Experimental Biology, Academia Sinica, Shanghai, China.

1964-1983: Deputy Director, Institute of Experimental Biology, which in 1978 was renamed as the Shanghai Institute of Cell Biology, Chinese Academy of Sciences.

1984- Research Professor, Shanghai Institute of Cell Biology, CAS.

Research Interest:

1) Embryonic stem cells, induced differentiation etc.

2) Cancer cell biology

Honors:

1980: Elected as a Member, Division of Biology, Chinese Academy of Sciences

1982: Organizer,International Workshop-Symposium of Chemical Carcinogenesis: Chemical, Mctabolic and Biological Aspects. Under the auspices of the Chinese Academy of Sciences and the National Foundation for Cancer Research,USA.October,1982, Shanghai, China.

1984: Organizer, Satellite Symposium of the Third International Congress on Cell Biology in Tokyo Japan on Organization and function of genomes particular emphasis on gene regulation September, 1984,Shanghai, China.

1983-86,1995-99: President, Chinese Society for Cell Biology

1988-90: President, Asian-Pacific Organization for Cell Biology (APOCB)

1990: Organizer, First Congress of Asian-Pacific Organization for Cell Biology, November, 1990, Shanghai, China.

1990: Editor-in-Chief, Cell Research, a journal reporting on basic research in the fields of animal and plant cell biology published in English.

Selected publications:

1942: Yao T, S Pai. Heteropycnosis and chromatin diminution in Cosmocerca sp. Science Record 1 (1-2) 197-202.

1945: Yao T. Studies on the organizer problem in Pelmatohydra oligactis. I, II, III. J Exp Biol 21(3-4) 147-60.

1950: Yao T. Cytochemical studies on the embryonic development of Drosophila melanogester. II. Alkaline and acid phosphatases. Quart J Microscop Sci 91(part 1) 79-88.

1956: Yao T, CY Cheng. Properties and changes of phosphatase activity during Drosophila metamorphosis. Acta Biol Exp Sinica 5(1) 123-36.

1977: Shi WK, Lu YL, Ye M, Z Yao. Membrane-associated embryonic antigen on human hepatocellular carninoma cells Acta Zool Sinica 23(4) 337-44.

1980a: Tsung HC, Shi WK, Z Yao. In situ localization of tumor associated antigen in human primary hepatoma cells. Acta Biol Exp Sinica 13(3) 317-29.

1980b: Yao Z. Aspects of research studies on liver carcinoma. In: Paul A Marks ed, Cancer Research in the People's Republic of China and the United States of America. Grune and Stratton Inc PP 145-60.

1982: Shi WK, Chen ZK, Z Yao. Differential response of F9 mouse teratocarcinoma cells to retinoic acid. Acta Biol Exp Sinica 15(1) 341-55.

1983: Tsung HC, Z Yao. Preliminary study of the characteristics of two cloned F9 teratocarcinoma cells. Ditto 16(1) 93-105.

1984: Tsung HC, Z Yao. The induced differentiation of the cloned B7-2 embryonal carcinoma cells by hexamethylene bisacetamide (HMBA). Ditto 17(3) 309-21.

1985a: Hsu WM, Song QB, Z Yao. Hybrids between F9 "nullipotent" teratocarcinoma cells and rat thymus cells produce differentiated cells. Ditto 18(2) 177-87.

1985b: Yao Z, HC Tsung. Influences of in vivo microenvironment on the differentiation of cloned B7-2 embryonal carcinoma cells. Ditto 18(2) 239-49.

1985c: Xie H, Z Yao et al. Two mouse hybridoma secreting monoclonal antibodies against human liver carcinoma and their antibody specificity. Ditto 18(2) 239-49.

1987: Tsung HC, Z Yao. Some biological characteristics and karyotype analysis of a mouse embryonic stem cell line ES-8501 cells. Dotto 20(2) 237-51.

1991a: Xu J, Tsung HC, Z Yao. Induced differentiation of mouse embryonic stem cells by retinoic acid and dibutyryl cyclic adenosine monophosphate. Ditto 24(2)353-67.

1991b: Fuhrer JP, Xie H, Murphy MJ, Ye JN, Z Yao. Characterization of a membrane-associated glycoprotein (gp 43) on human hepatocallula carcinoma by a monoclonal antibody. Cancer Res 51(4) 2158-63.

1993: Zeng ZC et al. Radioimmunotherapy for unresectable hepatocellular carcinoma using 131-Hepama-1 mAb: preliminary results. J Cancer Res Clin Oncol 119:257-9.

1995: Tsung HC, Xia SH, Xu LX, Li XL, Shi WK, Z Yao. Expression of exogenous porcine transforming growth beta-1 gene in ES cells and its effect on their differentiation in vitro. Acta Biol Exp Sinica 28(2) 173-89.

1996a: Tsung HC and Z Yao. The mechanism of vasculogenesis: The critical role of transforming growth factor-b1 in the formation of vessel-like structures during the differentiation in vitro of murine embryonic stem cells. Ditto 29(3)273-285.

1996b: Tsung HC, Xu J, Xu LX, Li XL, Shi WK, Z Yao. Can overexpression of TGF-b1 gene change the sex ratio in transgenic mice. Cell Res 6(1) 55-63.

1998a: Du ZW, Tsung HC, Z Yao. Expression of retinoic acid receptor γ gene in ES cells and its effect on their differentiation and apoptosis. Acta Biol Exp Sinica 31(2) 155-69.

1998b: Zhang XJ, Tsung HC, Chen JP, Li XL, Yao Z, Han ZC. Vasculogenesis from embroyoic bodies of murine embryonic stem cells transfected by TGF-β1 gene. Endothelium 6:95-106

2001a: Forced expression of oct-4 gene influences differentiation of embryonic stem cell. Chinese Science Bulletin 46:730-3

2001b: Du ZW, Tsung HC, Yao Z. Identification of putative downstream genes of oct-4 by suppression subtractive hybridization. Biochem Biophys Res Commun 282:701-6

2003: Tsung HC, Du Z, Rui R, Li XL, Bao LP, Wu J, Bao SM, Yao Z. The culture and establishment of embryonic germ (EG) cell lines from Chinese mini swine. Cell Res 13:195-202

2005: Wu da Y, Yao Z. Isolation and characterization of the murine Nanog gene promoter. Cell Res 15:317-324

Cell Research Online (CRO) published bimonthly

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