Cell Research

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Bone marrow-derived pancreatic stellate cells in rats(FREE)
Gisela Sparmann, Marie-Luise Kruse, Nicole Hofmeister-Mielke, Dirk Koczan, Robert Jaster, Stefan Liebe, Daniel Wolff and Jörg Emmrich

REVIEW
PPARs: diverse regulators in energy metabolism and metabolic diseases(FREE)
Yong-Xu Wang

ORIGINAL ARTICLES
A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis(FREE)
Lin Teng, Jian Zhao, Feifei Wang, Lan Ma and Gang Pei

Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4
Chengyang Huang, Yang Xiang, Yanru Wang, Xia Li, Longyong Xu, Ziqi Zhu, Ting Zhang, Qingqing Zhu, Kejing Zhang, Naihe Jing and Charlie Degui Chen

Structural insights into a novel histone demethylase PHF8
Lin Yu, Yang Wang, Shuo Huang, Jianjun Wang, Zengqin Deng, Qi Zhang, Wei Wu, Xingliang Zhang, Zhao Liu, Weimin Gong and Zhongzhou Chen

ATF4 regulates lipid metabolism and thermogenesis
Chunxia Wang, Zhiying Huang, Ying Du, Ying Cheng, Shanghai Chen and Feifan Guo

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Vol 20, No 2, 2010

ISSN: 1001-0602
EISSN: 1748-7838

2008 impact factor 4.535*

(ISI, Thomson Reuters, 2009)
45/157 Cell Biology

Editorial: A special issue on TGF-β signaling

TGF-β-initiated signaling is undoubtedly one of the most important and well investigated signaling events as TGF-β controls cell proliferation, differentiation, death and motility, and therefore plays an essential role in embryonic patterning and homeostasis of adult tissues. Deregulation of TGF-β signaling has been shown to be associated with several major diseases. Much has been learnt about the Smad-mediated canonical TGF-β signaling pathway in the last decade. However, modulation of this pathway via regulation of protein stability and subcellular localization, the crosstalk between the TGF-β/Smad pathway and other signaling pathways, and Smad-independent TGF-β signaling pathways just starts to become clear. This special issue presents 10 review articles covering current understanding of these major issues as well as the physiological and pathological roles of TGF-β in stem cell self-renewal, cell differentiation, angiogenesis and cancer metastasis.

Focus issues on "cell signaling Review Series"

Totally eight review articles focus on cell signalling are published in three issues. We hope that our readers find these papers useful to their research.

May 2008; 18(5):523-548.
Apr 2008; 18 (4):436 - 457.
Mar 2008; 18 (3):334 - 349.

Editorial: A special issue on DNA damage responses and genome maintenance

In this special issue, Cell Research presents a series of reviews covering cellular mechanisms that ensure the integrity of the genome. There are two classes of genome-maintenance systems, one responsible for accurately propagating the genetic information in DNA, and the other responsible for proper processing of DNA damage caused by various endogenous and exogenous agents.

This issue has been highlighted on nature.com as a special feature.

A focus issue on "RNA"

We collected several review articles for RNA and shared with our readers. More papers about this issue will be added to this collcetion.

Editorial: Cancer research in China: a Special Focus by Cell Research

The year of 2007 is the 100th anniversary of the American Association for Cancer Research (AACR), "marking a century of progress in saving lives through cancer research" (quote from the AACR website). Along with the rapid pace of growth of scientific research in China, the field of cancer research has also seen more and more prominent contributions by Chinese scientists. The editors of Cell Research, China's premium international journal in life sciences, have selected a number of outstanding papers on cancer research that have come out of China in the last few years to be the subject of commentaries by the authors of these articles.

Editorial: A special issue on "Stem Cell"

Stem cells possess the remarkable ability of extensive self-renewal and differentiation into specific cell lineages, and they play essential roles in development and adult tissue homeostasis. Due to their critical importance in normal physiology and the promise for use in regenerative medicine to treat a variety of diseases, stem cells have attracted extensive research interest in recent years. As China's premium international journal with a broad scope in cell and molecular biology, Cell Research has witnessed more and more submissions on stem cell research. Indeed, along with the traditional strengths of the journal in molecular immunology, cancer biology, and plant molecular physiology, stem cell research has gradually and naturally evolved into a new growth point of Cell Research. Reflecting the growing interest of both our readers and authors in this exciting and expanding field, we are pleased to present this Special Issue on Stem Cell Research.

Editorial: A special issue on "Plant Molecular Biology"

The use of molecular biology and genomics tools in plant biology research has greatly expanded our understanding of the molecular mechanisms that underlie plant development and physiology. The successful establishment of research resources such as mutant populations has led to progress in a variety of fields, including plant reproductive development, signal transduction, hormone functions, defense responses and epigenetic control. In the future these advances will potentially facilitate crop improvement through molecular breeding. In conjunction with the successful "International Conference on the Frontiers of Plant Molecular Biology, Chinese Academy of Sciences (2005)" recently held in Shanghai (27-29th, Oct, 2005), Cell Research is pleased to publish a special issue on "Plant Molecular Biology".