Cell Research

AOP
Differential remodeling of a T-cell transcriptome following CD8- versus CD3-induced signaling(FREE)
S Hussain I Abidi, Tao Dong, Mai T Vuong, Vattipally B Sreenu, Sarah L Rowland-Jones, Edward J Evans and Simon J Davis

REVIEWS
Wnt signaling and stem cell control(FREE)
Roel Nusse

Genomic analysis of epithelial ovarian cancer
John Farley, Laurent L Ozbun and Michael J Birrer

ORIGINAL ARTICLES
MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth
Julia Schultz, Peter Lorenz, Gerd Gross, Saleh Ibrahim and Manfred Kunz

Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors
Jing Liao, Zhao Wu, Ying Wang, Lu Cheng, Chun Cui, Yuan Gao, Taotao Chen, Lingjun Rao, Siye Chen, Nannan Jia, Huiming Dai, Shunmei Xin, Jiuhong Kang, Gang Pei and Lei Xiao

more>>

Vol 18, No 5, 2008

ISSN: 1001-0602
EISSN: 1748-7838

2006 impact factor 3.426*

(ISI, Thomson 2007)
62/156 Cell Biology

More new lines of human parthenogenetic embryonic stem cells

Linzhao Cheng

Cyclin B1: conductor of mitotic symphony orchestra

Huijuan Yu and Xuebiao Yao

Two papers published in a recent issue of Cell Research describe the derivation of pluripotent human embryonic stem (hES)-like cell lines from parthenogeneic blastocysts. These two papers complement and substantiate two other papers published a few months earlier, which described seemingly two classes of pathenogenetic hES cell lines. Together, these 4 papers mark the beginning of a new era in hES cell research: parthenogenetic hES cell lines come of age.

In this issue of Cell Research, Zhang and his colleagues, in an effort to delineate the function of cyclin B1 in mitosis, carried out a thorough analysis of cyclin B1 distribution in mammalian cells. They demonstrated that cyclin B1 is preferentially localized to unattached kinetochores and involved in chromosome alignment in mitosis. In addition, they provided evidence that the CDK1 population at kinetochores is in fact active and that the abundance of the complex varies during mitotic progression.

Focus issues on "cell signaling Review Series"

Totally eight review articles focus on cell signalling are published in three issues. We hope that our readers find these papers useful to their research.

May 2008; 18(5):523-548.
Apr 2008; 18 (4):436 - 457.
Mar 2008; 18 (3):334 - 349.

Editorial: A special issue on DNA damage responses and genome maintenance

In this special issue, Cell Research presents a series of reviews covering cellular mechanisms that ensure the integrity of the genome. There are two classes of genome-maintenance systems, one responsible for accurately propagating the genetic information in DNA, and the other responsible for proper processing of DNA damage caused by various endogenous and exogenous agents.

This issue has been highlighted on nature.com as a special feature.

A focus issue on "RNA"

We collected several review articles for RNA and shared with our readers. More papers about this issue will be added to this collcetion.

Editorial: Cancer research in China: a Special Focus by Cell Research

The year of 2007 is the 100th anniversary of the American Association for Cancer Research (AACR), "marking a century of progress in saving lives through cancer research" (quote from the AACR website). Along with the rapid pace of growth of scientific research in China, the field of cancer research has also seen more and more prominent contributions by Chinese scientists. The editors of Cell Research, China's premium international journal in life sciences, have selected a number of outstanding papers on cancer research that have come out of China in the last few years to be the subject of commentaries by the authors of these articles.

Editorial: A special issue on "Stem Cel"

Stem cells possess the remarkable ability of extensive self-renewal and differentiation into specific cell lineages, and they play essential roles in development and adult tissue homeostasis. Due to their critical importance in normal physiology and the promise for use in regenerative medicine to treat a variety of diseases, stem cells have attracted extensive research interest in recent years. As China's premium international journal with a broad scope in cell and molecular biology, Cell Research has witnessed more and more submissions on stem cell research. Indeed, along with the traditional strengths of the journal in molecular immunology, cancer biology, and plant molecular physiology, stem cell research has gradually and naturally evolved into a new growth point of Cell Research. Reflecting the growing interest of both our readers and authors in this exciting and expanding field, we are pleased to present this Special Issue on Stem Cell Research.

Editorial: A special issue on "Plant Molecular Biology"

The use of molecular biology and genomics tools in plant biology research has greatly expanded our understanding of the molecular mechanisms that underlie plant development and physiology. The successful establishment of research resources such as mutant populations has led to progress in a variety of fields, including plant reproductive development, signal transduction, hormone functions, defense responses and epigenetic control. In the future these advances will potentially facilitate crop improvement through molecular breeding. In conjunction with the successful "International Conference on the Frontiers of Plant Molecular Biology, Chinese Academy of Sciences (2005)" recently held in Shanghai (27-29th, Oct, 2005), Cell Research is pleased to publish a special issue on "Plant Molecular Biology".