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Controlling the diversity of cell populations in a stem cell culture
Inha Heo1 and Hans Clevers1
1Hubrecht Institute, Royal Academy of Arts and Science (KNAW) and University Medical Centre Utrecht, Uppsalalaan 8, 3584CT, Utrecht, The Netherlands
* Correspondence: Hans Clevers,
Culturing intestinal stem cells into 3D organoids results in heterogeneous cell populations, reflecting the in vivo cell type diversity. In a recent paper published in Nature, Wang et al. established a culture condition for a highly homogeneous population of intestinal stem cells.
Cell Research (2011) 21:373-374. doi:10.1038/cr.2011.33; published online 3 March 2011
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