Volume 36, No 3, Mar 2026

ISSN: 1001-0602 
EISSN: 1748-7838  
2020 impact factor 25.617*  
(Clarivate Analytics, 2021)

About the cover

Inspired by the bronze tree of Sanxingdui, this artwork illustrates the essential role of R-loops in early mammalian embryonic development. Golden helices intertwined among the branches depict how the resolution of R-loops releases paused RNA polymerase II to drive the maternal-to-zygotic transition, whereas their absence results in developmental arrest, highlighting R-loops-mediated transcriptional regulation at the dawn of life.See page 181–196 by Yaoyi Li et al. for details.

Advanced Online Publication: 23 Mar 2026

ORIGINAL ARTICLES

Social status impacts T-cell responses through synapse strength in the prefrontal cortex

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Current Issue: Vol.36 (Mar 2026)

RESEARCH HIGHLIGHTS

Boosting immunotherapy by restoring cryptic APC function
Targeting NNMT in fibroblasts reawakens T cells and restores antitumor immunity
ZBP1 links infections to cancer immunotherapy
Intestinal GAPs: neuro–epithelial–immune modules for liver protection

ORIGINAL ARTICLES

R-loops orchestrate RNAPII transcriptional reprogramming for the maternal-to-zygotic transition
Dynamic magneto-mechanical force in lysosomes induces durable macrophage repolarization for antitumor immunity
Asymmetric division in a two-cell-like state rejuvenates embryonic stem cells

LETTERS TO THE EDITOR

Efficient chemical reprogramming of human T cells to pluripotent stem cells

CORRIGENDA

Correction: ZBP1 links infections to cancer immunotherapy