Volume 33, No 9, Sep 2023

ISSN: 1001-0602 
EISSN: 1748-7838  
2020 impact factor 25.617*  
(Clarivate Analytics, 2021)

About the cover

The image shows a Chinese idiom of “flying together”, wherein one bird represents “Cultured Embryo” and the other bird represents “E-assembloid”, and they carry the keys to together open the black box of human peri-implantation development. See page 661–678 by Zongyong Ai et al. for details.

Advanced Online Publication: 16 Aug 2023

RESEARCH HIGHLIGHTS

Heartbreakers: innate sensors ZBP1 and cGAS linked to cardiotoxicity

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Current Issue: Vol.33 (Sep 2023)

EDITORIAL

Treating lung cancer: defining surgical curative time window

RESEARCH HIGHLIGHTS

Unveiling the hidden battlefield: dissecting the invasive zone in liver cancer
Lactylation regulates cardiac function
Atypical bacterial Argonautes regulate antiphage defense
Sensing unsaturated fatty acids: insights from GPR120 signaling
Towards clinically meaningful expansion of human HSCs

ORIGINAL ARTICLES

Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids
α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure
Structural insights into dimerization and activation of the mGlu2–mGlu3 and mGlu2–mGlu4 heterodimers
Lin28a maintains a subset of adult muscle stem cells in an embryonic-like state

LETTERS TO THE EDITOR

Nm-Mut-seq: a base-resolution quantitative method for mapping transcriptome-wide 2′-O-methylation
Cryo-EM structure of the ssDNA-activated SPARTA complex