Volume 35, No 4, Apr 2025

ISSN: 1001-0602 
EISSN: 1748-7838  
2020 impact factor 25.617*  
(Clarivate Analytics, 2021)

About the cover

To help the soldiers (T cells) better identify spies (non-self antigens, marked in blue) and protect the city, while avoiding harm to normal citizens (self-antigens, marked in orange), we need to improve the functionalities of two weapons: a blue glove or a blue goggle (T cell receptor, TCR) and a sword or a bow (CD8). Optimization of both weapons and their cooperation will significantly strengthen the soldiers’ power. See page 265–283 by Rui Qin et al. for details.

Advanced Online Publication: 3 Apr 2025

LETTERS TO THE EDITOR

Mechanisms of chromatin remodeling by the human Snf2-type ATPase SNF2H

REVIEW ARTICLE

Pyroptosis: molecular mechanisms and roles in disease

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Current Issue: Vol.35 (Apr 2025)

RESEARCH HIGHLIGHTS

Raptin, a novel brain hormone links sleep health to body weight gain
Stressing out the intestinal microbiota via a brain-neuroglandular circuit
A GSDMD agonist boosts specific antitumor immunity
Triaptosis: an endosome-dependent cell death modality
Tug of war between phosphatase and kinase during sleep
Astrocytes: emerging stars of engrams

ORIGINAL ARTICLES

A force-sensitive adhesion GPCR is required for equilibrioception
TCR catch bonds nonlinearly control CD8 cooperation to shape T cell specificity
Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator
Structural insights into spliceosome fidelity: DHX35–GPATCH1- mediated rejection of aberrant splicing substrates

LETTERS TO THE EDITOR

The conjugation-associated linear-BAC iterative assembling (CALBIA) method for cloning 2.1-Mb human chromosomal DNAs in bacteria
Structural basis of phosphate export by human XPR1

CORRIGENDA

Author Correction: The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb