Volume 35, No 12, Dec 2025

ISSN: 1001-0602 
EISSN: 1748-7838  
2020 impact factor 25.617*  
(Clarivate Analytics, 2021)

About the cover

A novel cell culture system, represented by the gourd and liquid, enabled generation of BPSCs with greater developmental potential. Nourished by the precious fluids, BPSCs gave rise to early mouse embryos. See page 954–969 by Kuisheng Liu et al. for details.

Advanced Online Publication: 13 Nov 2025

RESEARCH HIGHLIGHTS

Branched-chain fatty acids fire up the peroxisome

ZBP1 links infections to cancer immunotherapy

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Current Issue: Vol.35 (Dec 2025)

EDITORIAL

Sanofi-Cell Research outstanding paper award of 2024

RESEARCH HIGHLIGHTS

KCNQ1 and PIP₂: it takes two to tango
CNS gatekeepers: IFNγ-activated dendritic cells control leptomeningeal metastasis
Gut microbiota fuels clonal hematopoiesis
Psychedelics target neuroimmune interactions to limit fear
Too sweet to be savory: how fructose elicits microglia-driven disturbance of neurodevelopment
Antibiotics deliver a gut punch to infant immunity

ORIGINAL ARTICLES

Glucose starvation mimetic aldometanib removes immune barriers permitting mice with hepatocellular carcinoma to live to normal ages
Modeling post-gastrula development via bidirectional pluripotent stem cells
Harnessing alternative splicing for off-the-shelf mRNA neoantigen vaccines in hepatocellular carcinoma
Targeted destruction of VISTA boosts anti-tumor immunotherapy
Destruction of VISTA by TRIM25 ablation in T cells potentiates cancer immunotherapy
The molecular basis of μ-opioid receptor signaling plasticity
Genomic and transcriptomic dynamics in the stepwise progression of lung adenocarcinoma
Activation of the SPARDA defense system by filament assembly using a beta-relay signaling mechanism widespread in prokaryotic Argonautes

LETTERS TO THE EDITOR

Nearly complete redirection of insertion-type indel into recombination enhances knock-in and facilitates endogenous biomolecular condensate analysis