Volume 33, No 3, Mar 2023

ISSN: 1001-0602 
EISSN: 1748-7838  
2020 impact factor 25.617*  
(Clarivate Analytics, 2021)

About the cover

A study revealed that SARS-CoV-2 generates Z-RNA during virus infection. The left-handed Z-RNA ignites ZBP1-RIPK3-MLKL necroptosis pathway. The RIPK3 scaffolding functionality additionally promotes chemokine production to magnify the inflammatory responses. These synergistically lead to SARS-CoV-2-triggered lung damage and COVID-19. See page 201–214 by Shufen Li et al. for details.

Advanced Online Publication: 15 Mar 2023

LETTERS TO THE EDITOR

H3K4me2/3 modulate the stability of RNA polymerase II pausing

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Current Issue: Vol.33 (Mar 2023)

RESEARCH HIGHLIGHTS

mTOR gets greasy: lysosomal sensing of cholesterol
Buckle up! How the nano-seatbelt MRAP1 fastens ACTH in its orthosteric seat
Objection non-responsive! How maternal immune activation in pregnancy weakens subsequent microglial immune response
An exploitable Achilles heel of MITF?
Immune checkpoint inhibitors as senolytic agents
Death receptor 5 rises to the occasion

ORIGINAL ARTICLES

SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to promote virus-induced inflammatory responses
Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria
The compact Casπ (Cas12l) ‘bracelet’ provides a unique structural platform for DNA manipulation
Fructose-1,6-bisphosphatase 1 dephosphorylates IκBα and suppresses colorectal tumorigenesis

LETTERS TO THE EDITOR

Repeated vaccination of inactivated SARS-CoV-2 vaccine dampens neutralizing antibodies against Omicron variants in breakthrough infection