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A gut feeling: diet-sensing mesenchymal cells regulate intestinal stem cell function

Julia Messina-Pacheco^1,2,3 , Alex Gregorieff^1,2,3,*

¹Department of Pathology, McGill University, Montreal, QC, Canada
²Cancer Research Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
³McGill Regenerative Medicine Network, McGill University, Montreal, QC, Canada
* Correspondence: Alex Gregorieff(alex.gregorieff@mcgill.ca)

Due to its remarkable regenerative capacity, the intestine and particularly intestinal stem cells (ISCs), have become a popular model for studying homeostasis, regeneration, and oncogenic transformation of adult mammalian tissues. In a recent paper published in Cell Research , Deng et al. report that Leptin receptor-positive mesenchymal cells surrounding intestinal crypts sense diet alterations and modulate ISC function via a stromal IGF1–epithelial IGF1R axis.

https://doi.org/10.1038/s41422-022-00658-2

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