Advanced Search

Submit Manuscript

ADVANCE ONLINE PUBLICATION

RESEARCH HIGHLIGHTS

A gut feeling: diet-sensing mesenchymal cells regulate intestinal stem cell function

Julia Messina-Pacheco1,2,3 , Alex Gregorieff1,2,3,*

1Department of Pathology, McGill University, Montreal, QC, Canada
2Cancer Research Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
3McGill Regenerative Medicine Network, McGill University, Montreal, QC, Canada
* Correspondence: Alex Gregorieff(alex.gregorieff@mcgill.ca)

Due to its remarkable regenerative capacity, the intestine and particularly intestinal stem cells (ISCs), have become a popular model for studying homeostasis, regeneration, and oncogenic transformation of adult mammalian tissues. In a recent paper published in Cell Research , Deng et al. report that Leptin receptor-positive mesenchymal cells surrounding intestinal crypts sense diet alterations and modulate ISC function via a stromal IGF1–epithelial IGF1R axis.

https://doi.org/10.1038/s41422-022-00658-2

FULL TEXT | PDF

Browse 231