ADVANCE ONLINE PUBLICATION  |  Open Access

LETTERS TO THE EDITOR

Structural basis for pore blockade of human voltage-gated calcium channel Cav1.3 by motion sickness drug cinnarizine

Xia Yao^1,†,* , Shuai Gao^1,† , Nieng Yan^1,*

¹Department of Molecular Biology, Princeton University, Princeton, NJ, USA
^†These authors contributed equally: Xia Yao, Shuai Gao
* Correspondence: Xia Yao(xiayao@princeton.edu)Nieng Yan(nyan@princeton.edu)

Dear Editor,

Voltage-gated calcium (Cav) channels regulate a broad range of physiological processes, such as muscle contraction, synaptic signal transduction, and hormone secretion.1 Cav1.3 channels belong to the L-type (L for long-lasting current) Cav subfamily (LTCC) and display diverse tissue distributions in brain, ear, heart, and endocrine organs.2 Of note, Cav1.3 channels are predominantly expressed in cochlea inner hair cells, whose normal development and synaptic transmission are crucial for proper auditory function.3

https://doi.org/10.1038/s41422-022-00663-5

FULL TEXT | PDF

Browse 433