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LETTERS TO THE EDITOR

Structural basis for pore blockade of human voltage-gated calcium channel Cav1.3 by motion sickness drug cinnarizine

Xia Yao1,†,* , Shuai Gao1,† , Nieng Yan1,*

1Department of Molecular Biology, Princeton University, Princeton, NJ, USA
These authors contributed equally: Xia Yao, Shuai Gao
* Correspondence: Xia Yao(xiayao@princeton.edu)Nieng Yan(nyan@princeton.edu)

Dear Editor,

Voltage-gated calcium (Cav) channels regulate a broad range of physiological processes, such as muscle contraction, synaptic signal transduction, and hormone secretion.1 Cav1.3 channels belong to the L-type (L for long-lasting current) Cav subfamily (LTCC) and display diverse tissue distributions in brain, ear, heart, and endocrine organs.2 Of note, Cav1.3 channels are predominantly expressed in cochlea inner hair cells, whose normal development and synaptic transmission are crucial for proper auditory function.3


https://doi.org/10.1038/s41422-022-00663-5

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