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Cytoskeleton grows p62 condensates for autophagy

Nobuo N. Noda1,2,*

1Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
2Institute of Microbial Chemistry (BIKAKEN), Tokyo, Japan
* Correspondence: Nobuo N. Noda(nn@igm.hokudai.ac.jp)

p62 body, a representative selective cargo for autophagy, is known to be formed via liquid–liquid phase separation, but its spatiotemporal regulation remains largely unknown. In a recent paper published in Cell Research , Feng et al. show that branched actin filaments and Myo1D collect stochastically formed nanoscale p62 bodies and grow them into micron-scale condensate, which is prerequisite for their autophagic degradation.

https://doi.org/10.1038/s41422-022-00671-5

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