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Cytoskeleton grows p62 condensates for autophagy
Nobuo N. Noda1,2,*1Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
p62 body, a representative selective cargo for autophagy, is known to be formed via liquid–liquid phase separation, but its spatiotemporal regulation remains largely unknown. In a recent paper published in Cell Research , Feng et al. show that branched actin filaments and Myo1D collect stochastically formed nanoscale p62 bodies and grow them into micron-scale condensate, which is prerequisite for their autophagic degradation.