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A structural platform for B cell receptor signaling

Wei Xie^1,* , Kai Wucherpfennig^2,* , Dinshaw J. Patel^3,*

¹College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, Chin
²Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Department of Immunology, Harvard Medical School, Boston, MA, USA
³Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
* Correspondence: Wei Xie(xie_wei@zju.edu.cn)Kai Wucherpfennig(kai_wucherpfennig@dfci.harvard.edu)Dinshaw J. Patel(pateld@mskcc.org)

Three groups recently determined the cryo-EM structures of full-length transmembrane B cell receptor (BCR) in its resting state, representing a key advance toward our understanding of BCR signaling. These findings explain the molecular principles underlying BCR assembly and provide opportunities for structure-guided rational engineering of BCRs for the treatment of hematological and autoimmune diseases.

https://doi.org/10.1038/s41422-022-00724-9

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