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A structural platform for B cell receptor signaling
Wei Xie1,* , Kai Wucherpfennig2,* , Dinshaw J. Patel3,*
1College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, ChinThree groups recently determined the cryo-EM structures of full-length transmembrane B cell receptor (BCR) in its resting state, representing a key advance toward our understanding of BCR signaling. These findings explain the molecular principles underlying BCR assembly and provide opportunities for structure-guided rational engineering of BCRs for the treatment of hematological and autoimmune diseases.
https://doi.org/10.1038/s41422-022-00724-9