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LETTERS TO THE EDITOR

Molecular recognition of itch-associated neuropeptides by bombesin receptors

Changyao Li1,2,† , Youwei Xu1,† , Heng Liu1,† , Hongmin Cai1 , Yi Jiang1,3 , H. Eric Xu1,2,4,* , Wanchao Yin1,2,5,*

1The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
2University of Chinese Academy of Sciences, Beijing, China
3Lingang Laboratory, Shanghai, China
4School of Life Science and Technology, ShanghaiTech University, Shanghai, China
5Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, Guangdong, China
These authors contributed equally: Changyao Li, Youwei Xu, Heng Liu
* Correspondence: H. Eric Xu(eric.xu@simm.ac.cn)Wanchao Yin(wcyin@simm.ac.cn)

Dear Editor,

Itch, especially persistent itch (or chronic pruritus) in patients with allergic skin diseases and/or neuropathic problems, significantly affects sleep, mood and individual health. Extensive efforts have been made to develop novel therapeutic strategies to fight itch. Unfortunately, there is no FDA-approved treatment for chronic pruritus despite great efforts in antipruritic research in the past few decades.1


https://doi.org/10.1038/s41422-022-00743-6

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