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LETTERS TO THE EDITOR

Molecular recognition of itch-associated neuropeptides by bombesin receptors

Changyao Li^1,2,† , Youwei Xu^1,† , Heng Liu^1,† , Hongmin Cai¹ , Yi Jiang^1,3 , H. Eric Xu^1,2,4,* , Wanchao Yin^1,2,5,*

¹The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
²University of Chinese Academy of Sciences, Beijing, China
³Lingang Laboratory, Shanghai, China
⁴School of Life Science and Technology, ShanghaiTech University, Shanghai, China
⁵Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, Guangdong, China
^†These authors contributed equally: Changyao Li, Youwei Xu, Heng Liu
* Correspondence: H. Eric Xu(eric.xu@simm.ac.cn)Wanchao Yin(wcyin@simm.ac.cn)

Dear Editor,

Itch, especially persistent itch (or chronic pruritus) in patients with allergic skin diseases and/or neuropathic problems, significantly affects sleep, mood and individual health. Extensive efforts have been made to develop novel therapeutic strategies to fight itch. Unfortunately, there is no FDA-approved treatment for chronic pruritus despite great efforts in antipruritic research in the past few decades.1

https://doi.org/10.1038/s41422-022-00743-6

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