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Molecular recognition of itch-associated neuropeptides by bombesin receptors
Changyao Li1,2,† , Youwei Xu1,† , Heng Liu1,† , Hongmin Cai1 , Yi Jiang1,3 , H. Eric Xu1,2,4,* , Wanchao Yin1,2,5,*
1The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, ChinaDear Editor,
Itch, especially persistent itch (or chronic pruritus) in patients with allergic skin diseases and/or neuropathic problems, significantly affects sleep, mood and individual health. Extensive efforts have been made to develop novel therapeutic strategies to fight itch. Unfortunately, there is no FDA-approved treatment for chronic pruritus despite great efforts in antipruritic research in the past few decades.1
https://doi.org/10.1038/s41422-022-00743-6