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A new route for EV biogenesis.

Li Yu

State Key Laboratory of Membrane Biology, Tsinghua University–Peking University Joint Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, China
* Correspondence: Li Yu(liyulab@mail.tsinghua.edu.cn)

Exosomes are known to be generated in multivesicular bodies, a subset of endosomes. A recent study by Gao and colleagues uncovers a new type of small extracellular vesicle, which is generated by a different route involving non-canonical autophagy and a previously unknown intermediate organelle named by the authors as RAB22A-mediated non-canonical autophagosome fused with early endosome (Rafeesome).

https://doi.org/10.1038/s41422-022-00747-2

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