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How pain sensors make the gut weep

Nathalie Stakenborg , Yaping Xue , Guy Boeckxstaens

Center of Intestinal Neuro-immune interaction, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium
* Correspondence: Guy Boeckxstaens(guy.boeckxstaens@kuleuven.be)

Nociceptors in the gut are widely known for transmitting pain signals to the spinal cord. Yang et al. now identified a novel microbiome-nociceptor-goblet cell crosstalk that protects the intestinal epithelial barrier by triggering mucus secretion.

https://doi.org/10.1038/s41422-022-00768-x

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